Lanthella basta

Franklin, M.A. Penn, S.G. Lebrilla, C.B. Lam, T.H. Pessah, I.N. Molinski, T.F. (1996) Bastadin 20 and bastadin O-sulfate esters from lanthella basta novel modulators of the RyiR FKBP12 rec tor complex. J.Nat. Prod., 59,1121-7. 

Pettit, G.R. Butler, M.S. Williams, M.D. Filiatrault, M.J. Pettit, R.K. (1996) Isolation and structure of hemibastadinols 1 -3 from the Papua New Guinea marine sponge lanthella basta. J. Nat. Prod., 59,927-34. 

Pettit GR, Butler MS, Williams MD, Filiatrault MJ, Pettit RK (1996) Isolation and Structure of Hemibastadinols 1-3 from the Papua New Guinea Marine Sponge lanthella basta. J Nat Prod 59 927... 

Masuno MN, Hoepker AC, Pessah IN, Molinski TF (2004) 1 -O-Sulfatobastadins-1 and -2 from lanthella basta (Pallas). Antagonists of the RyRl-FKBP12 Ca2+ Channel. Mar Drugs 2 176... 

Cheshire, A. C., Wilkinson, C. R., et at. (1997). Bathymetric and seasonal changes in photosynthesis and respiration of the phototrophic sponge Phyllospongia lamellose in comparison with respiration by the heterotrophic sponge lanthella basta on Davies Reef, Great Barrier Reef. Marine and Freshwater Research 48, 589—599. 

Bromotyrosine-derived metabolites are often encountered in marine sponges of the families Aplysinidae and Pseudocer-atidae, in particular Pseudoceratina (= Psammaplysilla) purpurea. They show a variety of biological activities, which include antimicrobial, enzyme inhibitory, and antifouling activities. Psammaplysin A (47) is antimicrobial, cytotoxic, and antifouling, whereas psammaplin A (48) is an inhibitor of histone deacetylase (2). The marine sponge lanthella basta synthesizes at least 25 bastadins that are linear or cyclic peptides composed of four bromotyrosine residues [bastadin 5 (49)] and show antimicrobial, cytotoxic, and enzyme inhibitory activities as well as interaction with Ca + channels (21). 

Several carotenoids have been isolated from marine sponges 142), for example the main carotenoids of Microciona prolifera 143) and a carotenoid sulfate, bastaxanthin (222a), from lanthella basta 144). Bastaxanthin (222a) was the first known naturally occurring carotenoid sulfate. 

Kazlauskas, R., R.O. Lidgard, P.T. Murphy, and R.J. Wells Brominated Tyrosine-Derived Metabolites from the Sponge lanthella basta. Tetrahedron Lett. 21, 2277 (1980). 

The other series is the bastadins, named after the Australian species lanthella basta, from which most bastadins were isolated (Kazlauskas et al., 1981). They are formally peptides that are derived, as in other verongid sponges, from bromotyrosine. With the exception of bas-tadin 14, which was isolated from Psammaplysilla purpurea, and bastadins 22 and 23 from Dendrilla cactos, almost all bastadins were extracted from species of the genus lanthella, most often from lanthella basta. The latest member of the series is bastadin 26, isolated from the Australian species lanthella flabelliformis (Calcul et al., 2010b Carroll et al, 2010). 

Kazlauskas, R., Lidgard, R.O., Murphy, P.T, Wells, R.J., and Blount, J. F. (1981) Brominated tyrosine-derived metabolites from the sponge lanthella basta. Aust.J. Chem., 34, 765-786. 

Ramdahl, T, Kazlauskas, R., Bergquist, P., and Liaaen-Jensen, S. (1981) Carotenoids from the marine sponge lanthella basta. Biochem. Syst. Ecol., 9, 211-213. 

Mack, M.M., Molinski, T.E., Buck, E.D., and Pessah, I.N. (1994) Novel modulators of skeletal muscle FKBP12/calcium channel complex from lanthella basta. J. Biol. Chem., 269, 23236-23249. 

Miao, S., Andersen, R.J., and Allen, TM. (1990) Cytotoxic metabolites fi-om the sponge lanthella basta collected in Papua New Guinea. J. Nat. Prod., 53,1441-1446. 

Nishiyama, S., Suzuki, T, and Yamamura, S. (1982) Total synthesis of bastadin-6, a brominated tyrosine-derived metalrolite from sponge lanthella basta. Chem. Lett., 1851-1852. 

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