Lanthella

Franklin, M.A. Penn, S.G. Lebrilla, C.B. Lam, T.H. Pessah, I.N. Molinski, T.F. (1996) Bastadin 20 and bastadin O-sulfate esters from lanthella basta novel modulators of the RyiR FKBP12 rec tor complex. J.Nat. Prod., 59,1121-7. 

Okamoto, Y. Ojika, M. Sakagami, Y. (1999) lanthaan A, a dimoic polybrominated benzofuran as a Na,K-ATPase inhibitor from a marine sponge, lanthella sp. Tetrahedron Lett., 40, 507-10. 

Pettit, G.R. Butler, M.S. Williams, M.D. Filiatrault, M.J. Pettit, R.K. (1996) Isolation and structure of hemibastadinols 1 -3 from the Papua New Guinea marine sponge lanthella basta. J. Nat. Prod., 59,927-34. 

Okamoto Y, Ojika M, Sakagami Y (1999) Iantheran A, a Dimeric Polybrominated Benzo-furan as a Na,K-ATPase Inhibitor from a Marine Sponge, lanthella sp. Tetrahedron Lett 40 507... 

Pettit GR, Butler MS, Williams MD, Filiatrault MJ, Pettit RK (1996) Isolation and Structure of Hemibastadinols 1-3 from the Papua New Guinea Marine Sponge lanthella basta. J Nat Prod 59 927... 

Masuno MN, Hoepker AC, Pessah IN, Molinski TF (2004) 1 -O-Sulfatobastadins-1 and -2 from lanthella basta (Pallas). Antagonists of the RyRl-FKBP12 Ca2+ Channel. Mar Drugs 2 176... 

Aeroplysinin-1 (84) has been obtained from marine sponges belonging to the order Verongida. The first isolation of (+)-aeroplysinin-1 from Verongia aerophoha collected in the Bay of Naples (Italy) was reported by Fattorusso et al. in 1970 [77]. Since then, (-r)-aeroplysinin-l has been reported from a number of marine sponges from various geographic locations (see Table 9.2) and the (—)-isomer has been isolated from lanthella ardis ]78]. 

Cheshire, A. C., Wilkinson, C. R., et at. (1997). Bathymetric and seasonal changes in photosynthesis and respiration of the phototrophic sponge Phyllospongia lamellose in comparison with respiration by the heterotrophic sponge lanthella basta on Davies Reef, Great Barrier Reef. Marine and Freshwater Research 48, 589—599. 

Bromotyrosine-derived metabolites are often encountered in marine sponges of the families Aplysinidae and Pseudocer-atidae, in particular Pseudoceratina (= Psammaplysilla) purpurea. They show a variety of biological activities, which include antimicrobial, enzyme inhibitory, and antifouling activities. Psammaplysin A (47) is antimicrobial, cytotoxic, and antifouling, whereas psammaplin A (48) is an inhibitor of histone deacetylase (2). The marine sponge lanthella basta synthesizes at least 25 bastadins that are linear or cyclic peptides composed of four bromotyrosine residues [bastadin 5 (49)] and show antimicrobial, cytotoxic, and enzyme inhibitory activities as well as interaction with Ca + channels (21). 

M., Chin, M., and Sills, M. A. (1993) Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus lanthella. J Nat Prod. 56,1613-1617. 

SPECTRAL data UV, IR, PMR organism Aplysina (or Verongia) aerophoba, and lanthella sp. (Porifera) reference 300... 

SPECTRAL data IR, PMR organism lanthella ardis (Porifera) reference 106, 133, 134, 153... 

Aeroplysinin-1 Some six months after preliminary publication of structure (76) for Aeroplysinin -1 the enantiomorphic (—)-isomer was isolated from the Caribbean sponge lanthella ardis. C.d. data established the absolute configuration of the (—)-isomer as (78), and this was later confirmed by X-ray analysis. The X-ray structure of ( +)-Aeroplysinin-l was determined later. In the period under review, Minale et al. have reported the isolation of the new bromo-compound Aeroplysinin-2 (79) from V. aerophoba, and furthermore they have shown that the compound undergoes facile photochemical reaction to (80) in daylight. 

Several carotenoids have been isolated from marine sponges 142), for example the main carotenoids of Microciona prolifera 143) and a carotenoid sulfate, bastaxanthin (222a), from lanthella basta 144). Bastaxanthin (222a) was the first known naturally occurring carotenoid sulfate. 

Kazlauskas, R., R.O. Lidgard, P.T. Murphy, and R.J. Wells Brominated Tyrosine-Derived Metabolites from the Sponge lanthella basta. Tetrahedron Lett. 21, 2277 (1980). 

Aplysinidae lanthellidae Pseudoceratinidae Aiolochroia, Aplysina, Verongula AnomoiantheKa, Hexadella, lanthella Pseudoceratina... 

---