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Metabolite brominated, derived from tyrosine

Similar metabolites which appear to be derived from tyrosine and brominated tyrosine include botryllamides A-D (31-34), which were isolated from brightly coloured styelid ascidians from the genus Botryllus collected in Fiji and in Australia [32]. Botryllamide D was reported to exhibit marginal cytotoxicity after 72 hour exposure to the human colon cancer cell line HCT 116 (IC50 17 pg/mL), but were inactive in vivo. The rubrolides, which were isolated from Riterella rubra [33] may well be derived from precursors similar to the botryllamides, however, the rubrolides are not alkaloids so have been mentioned here only for comparative purposes. [Pg.241]

Kotoku N, Tsujita H, Hiramatsu A, Mori C, Koizumi N, Kobayashi M (2005) Efficient Total Synthesis of Bastadin 6, an Anti-Angiogenic Brominated Tyrosine-Derived Metabolite from Marine Sponge. Tetrahedron 61 7211... [Pg.469]

All of the Amathia brominated amides are presumably biosynthesised from amino acids by similar pathways in the related bryozoans. The amathamides are amides derived formally by reaction of 2-(2,4-dlbromo-5-methoxyphenyl)ethanamlne, 68, with proline followed variously by introduction of a double bond, or methyl, methoxy or bromine substituents. The A. convoluta metabolites 70-74, and 75 from A. alternata are all also derived formally from 2-(2,4-dibromo-5-methoxy-phenyDethanamlne, 68—either by direct amide formation with tyrosine, or by having an additional aminopropyl group which is then... [Pg.84]

Kazlauskas, R., R.O. Lidgard, P.T. Murphy, and R.J. Wells Brominated Tyrosine-Derived Metabolites from the Sponge lanthella basta. Tetrahedron Lett. 21, 2277 (1980). [Pg.328]

Kazlauskas, R., Lidgard, R.O., Murphy, P.T, Wells, R.J., and Blount, J. F. (1981) Brominated tyrosine-derived metabolites from the sponge lanthella basta. Aust.J. Chem., 34, 765-786. [Pg.1198]

Kotoku, N., Tsujita, H., Hiramatsu, A., Mori, C Koizumi, N and Kobayashi, M. (2005) Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge. Tetrahedron, 61, 7211—7218. [Pg.1284]


See other pages where Metabolite brominated, derived from tyrosine is mentioned: [Pg.126]    [Pg.184]    [Pg.844]    [Pg.599]    [Pg.183]    [Pg.719]    [Pg.12]    [Pg.128]   
See also in sourсe #XX -- [ Pg.126 ]




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