34-Sulfatobastadin from lanthella

Masuno MN, Hoepker AC, Pessah IN, Molinski TF (2004) 1 -O-Sulfatobastadins-1 and -2 from lanthella basta (Pallas). Antagonists of the RyRl-FKBP12 Ca2+ Channel. Mar Drugs 2 176... 

M., Chin, M., and Sills, M. A. (1993) Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus lanthella. J Nat Prod. 56,1613-1617. 

Two non-peptidic macrocyclic inhibitors of the ETa receptor have also been described. The bromotyrosine-derived macrolactam 34-sulfatobastadin 13 (33, Figure 8.13), isolated from the sponge lanthella sp., weakly inhibits the binding of [ I]-ET-1 to the ETa receptor with an IC50 of 39 pM. The polyketide (—)-kendomycin (34, TAN-2162, Figure 8.13) is a moderately potent inhibitor of both endothelin receptors (ETa IC5o = 11.5 pM ETb ICso = 2.9 pM), isolated from Streptomyces sp AL-71389. ... 

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