Lansoprazole dosage

Swallow lansoprazole delayed-release capsules whole. Do not chew or crush. Dosage adjustment For naproxen/lansoprazole, no adjustment of the 15 mg lansoprazole component is necessary in patients with renal insufficiency or for the elderly. However, consider dose adjustment for the naproxen component for patients with renal insufficiency, liver disease, or the elderly. 

Belal et al. [50] used an anodic polarographic method for the determination of omeprazole and lansoprazole in pure form and in pharmaceutical dosage forms. The study was carried out in Britton-Robinson buffer over the pH range 4.1—11.5. In Britton-Robinson buffer of pH 7, well-defined anodic waves were produced with diffusion-current constant (ft]) of 1.7 0.01 (n = 6) and 1.66 0.01 (n = 8) for lansoprazole and omeprazole, respectively. The current-concentration plots were rectilinear over the ranges of 4—24, 2—16 /using direct current (DCt) mode for lansoprazole and omeprazole, respectively, and over the range 2—18,... 

Omeprazole (p. 171) can cause maximal inhibition of HC1 secretion. Given orally in gastric juice-resistant capsules, it reaches parietal cells via the blood. In the acidic milieu of the mucosa, an active metabolite is formed and binds covalently to the ATP-driven proton pump (H+/K+-ATPase) that transports H+ in exchange for I<+ into the gastric juice. Lansoprazole, pantoprazole, and rabeprazole produce analogous effects. Omeprazole is a racemate. With respect to dosage, the now available (S)-omeprazole (esomeprazole) represents the more potent enantiomer, but this offers no therapeutic advantage. 

Erosive esophagitis . 10 mg Zollinger-Ellison syndrome fiO mg NSAID-induced gastric ulcers treatment and prevention Dosage form Delayed-relea.se capsules containing 15 and. 10 mg of lansoprazole in enteric-coated granules... 

Standard PPI dosages (e.g., omeprazole 20 mg/day and lansoprazole 30 mg/day) reduce the risk of NSAID-induced gastric ulcer and duodenal ulcer. " In a large comparative multicenter trial, omeprazole 20 mg/day was superior to ranitidine 150 mg twice daily in preventing NSAID-induced gastroduodenal ulcers. Two randomized controlled trials have compared PPIs with misoprostol and placebo. 

However, in 1998 the manufacturers of lansoprazole had on record two reports of possible interactions. An elderly patient taking warfarin developed an INR of 7 when lansoprazole was added. Despite a warfarin dosage adjustment he had a gastrointestinal haemorrhage, a myocardial infarction and died after 3 weeks. Another man taking warfarin (as well as amiodarone, furosemide and lisinopril) became confused, had hallucinations and developed an increased INR (value not known) when given lansoprazole. The lansoprazole was stopped after 4 days, and he then recovered. However, it is uncertain whether this was an interaction or whether he had taken an incorrect warfarin dosage because of his confusion. ... 

Not understood. A possible explanation is that if the dosage of omeprazole is high enough, it may possibly reduce the metabolism of phenytoin by CYP2C19. However, CYP2C19 has only a minor role in phenytoin metabolism. Esomeprazole may interact similarly. With lansoprazole, the overall picture is that it does not act as an enzyme inducer or inhibitor ... 

Information is limited, but what is eurrentiy known suggests that patients given omeprazole, and possibly esomeprazole, with diazepam may expe-rienee inereased benzodiazepine effeets (sedation, unstable gait ete). If this oeeurs the benzodiazepine dosage should be reduced. Lansoprazole, pantoprazole and rabeprazole do not appear to interaet with diazepam. 

Timmer W, Ripke H, Kleist P, Ehrlich A, Wieckhorst G, Lucker PW, Fuder H (1995) Effect of four lansoprazole dose levels and one dosage regimen of omeprazole on 24-hour intragastric pH in healthy subjects. Methods Find Exp Clin Pharmacol 17(7) 489-495... 

As opposed to lansoprazole and pantoprazole, hepatic metabolism seems to saturate at higher dosages of omeprazole (40 mg) [13]. Although dose linearity is a desirable feature, its advantages may be elusive since PPIs show considerable interindividual variation in bioavailability [14, 15]. 

Figure 1. Effective loads of PPIs used at standard dosages. Molar loads depend on dose and bioavailability and, according to elimination rates, translate into different values of AUC. Ome, omeprazole lanso, lansoprazole panto, pantoprazole.

Information on possible drug interactions with lansoprazole is incomplete [59]. Some pertinent drugs have been studied only at standard dosage (prednisone [60]), not at all (carbamazepine), or data were published only in descriptive terms (warfarin [61]). However, compounds representative of most CYP isoforms have been studied with negative results [20, 60], with the notable exception of 2D6 (not investigated). 

Tabata T, Makino T, Kashihara T, Hirai S, Kitamori N, Toguchi H (1992) Stabilization of a new antiulcer drug (lansoprazole) in the solid dosage forms. Drug Dev Ind Pharm 18 1437-1447... 

Chun AHC, Eason CJ, Shi HH, Cavanaugh JH (1995) Lansoprazole an alternative method of administration of a capsule dosage formulation. Clin Ther 17 441-447... 

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