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Langendorff preparation

An isolated mammalian heart whose extrinsic nervous connections have been severed will beat spontaneously for hours if it is supplied with a nutrient medium via the aortic trunk and coronary arteries (Langendorff preparation). In such a preparation, only those drugs that act directly on cardio-myocytes will alter contractile force and beating rate. [Pg.128]

Langendorff preparation An isolated heart preparation used to test drug effects on heart rate and contractile force. [Pg.320]

Isolated working heart preparation Perfusion of the heart ex vivo through the left atrium and ejection via the aorta resembling physiological conditions. Measurement of cardiac output. Preload and afterload can be adjusted. Other characteristics similar to Langendorff preparation. [Pg.60]

Left ventricular wedge preparation Langendorff preparation -In Vivo... [Pg.355]

Clements-Jewery H, Curtis MJ (2014) The Langendorff preparation, hr Ardehali H, Bolli R, Losordo DW (eds) Manual of research techniques in cardiovascular medicine. Wiley... [Pg.198]

The possible role of cellular glutathione status in the controlling sarcolemmal protein activity has been addressed by studying the effect of GSH, GSSG and several other thiol and disulphide compounds on Na/K ATPase activity using (1) an isolated bovine ventricular Na/K ATPase preparation (2) crude sarcolemmal preparations (biochemical studies) (c) Langendorff-perfiised isolated hearts (cytochemical studies) and (4) isolated ventricular myocytes (electrophysiologjcal studies). [Pg.64]

Rat hearts were harvested, prepared for perfusion in the Langendorff configuration as described in Methods [10,11], and divided into four groups as follows ... [Pg.50]

Activation Atrial preparation Biophysics Calcium channel Cardiac action potential Channel kinetics Comprehensive in vitro proarrhythmia assay Delayed rectifier Early afterdepolarisation ECG Hodgkin-Huxley ICHS7A ICHS7B In silico modelling Inactivation Inward rectifier Langendorff heart Purkinje fibre Safety assessment Sodium channel Stem cells... [Pg.150]

Cardiac SP in vivo methods primarily use conscious telemetered animals to assess the effects of the test item on the cardiovascular system. Variables that are recorded in the dog include blood pressure, heart rate and ECG (see Authier et al. 2015). Complementary studies, usually non-GLP in namre, include a number of in vitro assays that have been well characterised with utility in the safety profiling of an NCE. These assays include assessment of drug effects in the isolated guinea pig right atrium preparation, rabbit Purkmje fibre preparation, the isolated Langendorff heart and the isolated wedge preparation. Each assay will be briefly discussed. [Pg.153]

The cardiovascular action of SM to lower systemic blood pressure in the rats has been demonstrated. Langendorff cardiac preparation in guinea pig and four types of vasculature in dog, including coronary, renal, femorid, and mesenteric arteries are performed. SM induces dose-related hypotension without changing heart rate. Atropine, propranolol, and chlorpheniramine plus cimetidine antagonize the hypotensive effect. In the isolated whole-heart preparation, SM injection increases coronary blood flow and causes a positive inotropic action. SM relaxes all arteries at low concentration and contracts all, but the coronary artery, at high concentration (7P). [Pg.315]

Hearts can be perfused in two modes the working heart preparation and the isovolumic (or Langen-dorff) preparation. Both methods allow assessment of cardiac mechanical function throughout the experimental protocol. For both preparations, the ascending aorta is cannulated and retrograde perfusion of the aorta is initiated. In Langendorff... [Pg.601]

See other pages where Langendorff preparation is mentioned: [Pg.272]    [Pg.351]    [Pg.63]    [Pg.70]    [Pg.396]    [Pg.154]    [Pg.44]    [Pg.9]    [Pg.60]    [Pg.506]    [Pg.86]    [Pg.56]    [Pg.601]    [Pg.316]    [Pg.318]    [Pg.272]    [Pg.351]    [Pg.63]    [Pg.70]    [Pg.396]    [Pg.154]    [Pg.44]    [Pg.9]    [Pg.60]    [Pg.506]    [Pg.86]    [Pg.56]    [Pg.601]    [Pg.316]    [Pg.318]    [Pg.110]    [Pg.54]    [Pg.484]    [Pg.360]    [Pg.164]    [Pg.85]    [Pg.613]    [Pg.112]    [Pg.136]    [Pg.155]    [Pg.173]    [Pg.288]    [Pg.46]    [Pg.1203]    [Pg.226]   
See also in sourсe #XX -- [ Pg.128 ]

See also in sourсe #XX -- [ Pg.26 , Pg.60 ]



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