L-Phenoxypropan

Our results conci red with those above when 3-bromo-l-phenoxypropane was added to our Mg at room temperature the reaction was quite vigorous(40). Upon carbonation, followed by hydrolysis, the only acidic product isolated was phenol in 70% yield. It was very satisfying to note that at -78 °C the reaction of 3-phenoxypropyl bromide proceeded smoothly. 

SYNS 688A BENSYLYT 2-(N-BENZYL-2-CHLOROETHYLAMINO)-l-PHENOXYPROPANE HYDROCHLORIDE BENZYL(2-CHLOROETHYL)(l-METHYL-2-PHENOXYETHYL)AMINE HYDROCHLORIDE N-BENZYL-N-PHENOXYISOPROPYL-P-CHLORETHYLAMINE HYDROCHLORIDE ... 

AI3-14682 EINECS 212-222-7 NSC 24015 Phenoxyisopropanol 1-Phenoxy-2-propanol l-Phenoxypropan-2-ol 2-Phenoxy-1-methylethanol 2-Propanol, 1-phenoxy- Propylene phenoxetol. Liquid bp = 233", d20 = 134 d O = 1.0622. 

Substance classes Properties — Effectiveness — Applications 1.8 l-Phenoxypropan-2-ol... 

Because of its broad spectrum of effectiveness and its favourable dermatological properties l-phenoxypropan-2-ol is mentioned in the EC list of preservatives provisionally allowed for the protection of cosmetics with a maximum authorized concentration of 1% and for rinse-off products only. 

Although some workers have found difficulty in purifying the product, a particularly convenient preparation of chroman involves the cyclization of l-chloro-3-phenoxypropane in the presence of tin(IV) chloride (equation 11) (52CR(234)1787). The synthesis is readily adapted to give many substituted chromans. A surprising result was obtained using 3-chloro-... 

Table 4 Cyclization of Some m-Substituted 1,3-Diphenoxypropanes and 3-Phenoxypropan-l-ols...

A variation on this general theme which has not been as widely applied as the previous examples, but which is nevertheless of value, involves the use of 3-phenoxypropan-l-ols (66JOC3032, 67JCS(B)859). Here again it is observed that the m-substituted isomer cyclizes to a mixture of two chromans. 

This mixed reactivity is illustrated by the results of a recent reinvestigation of the reaction between 4-chloro-methyl-l,3,2-dioxathiolane K-oxide 33 and sodium phenoxide in ethanol (Scheme 3) <2000IZV1774, 2000RCB1753>. 3-Phenoxypropane-l,2-diol 35 has been obtained as the major product (45%), while only traces of... 

SYNS l,2-EPOXY-3-PHENOXYPROPANE 2,3-EPOXYPROPYLPHENYL ETHER FENYL-GLYCIDYLETHER (CZECH) GLYCIDYL PHENYL ETHER PGE PHENOL-GLYCIDAETHER (GERMAN)... 

In the preparation of 2-phenoxymethylperhydro-imidazo[l, 2-a]pyridine (221), the ring opening of 1,2-epoxy-3-phenoxypropane (219) with 2-aminopyridine followed by catalytic reduction of the hydrochloride of the resultant amino alcohol over Rh/C gave 220. Treatment of220 with thionyl chloride followed by base produced the required 221 (70IJC707). 

Hydrogen halides Acetamide. Ammonium acetate. Ammonium formate. Epichloro-hydrin. l,2-Epoxy-3-phenoxypropane. Ethylenediamine. Ethylene oxide. Magnesium oxide. Propylene oxide. 

Regioselective hydroxylation of aromatic compounds can also be achieved by using whole cells. For instance, 6-hydroxynicotinic acid (35) is produced industrially from nicotinic acid (34) by a Pseudomonas or Bacillus sp (equation 48) . Racemic prenalterol (37) has been obtained by regioselective p-hydroxylation of ( )-l-isopropylamino-3-phenoxypropan-2-ol (36) using Cunninghamella echinulata (equation 49) . 

The reaction between the epoxy and the end groups of the polyester was modeled by using l,2-epoxy-3-phenoxypropane and n-octanoic acid. An equimolar solution of the two was prepared in tetrahydrofuran (THF) with a catalytic amount of pyridine a few drops of this solution were placed on a NaCl window and the THF allowed to evaporate. The reaction was carried out at 100 °C, and the IR spectrum of the mixture was recorded every 15 min. Similar experiments were performed without a catalyst. The reaction between... 

Figure 2. Infrared spectrum of a mixture of l,2-epoxy-3-phenoxypropane and n-octanoic acid at 100 °C as a function of time, showing the rapid disappearance of acid carbonyl absorption in the presence of pyridine as a catalyst.

An early example by Reetz and co-workers [79] demonstrated the evaluation of a series of biocatalysts for the hydrolytic kinetic resolution of chiral glycidyl phenyl ethers. Employing a fused-silica reactor, the authors developed an integrated reaction system capable of performing biocatalytic hydrolysis, along with separation and detection of the reaction products. Using the enantioselective hydrolysis of 2-phenoxymethyloxirane (136) to 3-phenoxypropane-l,2-diol (137) as a model reaction (Table 6.14), the authors evaluated the biocatalytic activity of a series of epoxide... 

SYNONYMS l,2-epoxy-3-phenoxypropane, 2,3-epoxypropylphenyl ether, glycidyl phenyl ether, pge, phenoxy methyloxirane, phenyl-2,3-epoxypropyl ether. 

Di( 1-prop yll) ether Di(2-propynyl) ether Di n propo methane l,2 Epoxy-3-isopropoxy propane l,2 Epoxy-3-phenoxypropane Ethoxyacetophenone... 

Prepreg of 2,2 -propylidene-bis(l, 2-epoxy-3-phenoxypropane) polymerized with 0.2 moles of l,2-epoxy-3-phenoxypropane-(l-methylidene)-l,4-phenylene-oxy(2-propanol)... 

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