L-Cyclohexyl-3-

Glipi de. GHpi2ide (l-cyclohexyl-3[ -[2-(5-methylpyra2inecarboxamido)eth5l]phenyl]sulfonyl]urea), mol wt 445.55, forms crystals from ethanol, mp 208—209°C. It is known commercially as Glucotrol. 

Another example is a claim of possible industrial appHcation for preparing l-cyclohexyl-3,5-dimethylpyrazole [79580-49-7] (75) and similar compounds from 1,2,6-thiadiazine-l,1-dioxide (74) by extmsion of SO2 (eq. 20) (48). This process has the added advantage of not requiring hydrazine derivatives as reactants. 

Diaziridine, 1-cyclohexyl-hydrolysis rate constant, 7, 216 (62CB1759) Diaziridine, 1 -cyclohexyl-3,3-dimethyl-hydrolysis rate constant, 7, 216 (62CB1759) Diaziridine, l-cyclohexyl-3-methyl-hydrolysis rate constant, 7, 216 (62CB1759) Diaziridine, l,2-di-t-butyl-3-t-butylimino-IR, 7, 13 <80AG(E)276)... 

From l-cyclohexyl-3-ethyldiaziridine, crystalline derivatives have been prepared with p-toluenesulfonyl chloride and with 3,5-dinitro-benzoyl chloride, e.g., 46/ The quantitative liberation of iodine from acid iodide solution characterizes these compounds as true diaziridines. 

Calf thymus (CT) DNA was first fragmented by sonication, then purified by a standard procedure. Agarose gel electrophoresis for the sonicated CT DNA revealed a distribution in molecular weight ranging from 30 kDa to 260 kDa which is equivalent in base pairs (bp) from 40 to 400 (1 bp = 660 Da). The DNA fragments were reacted with HEDS in the presence of l-cyclohexyl-3-(2-morpholinoethyl) carbodi-imide metho-p-toluenesulfonate (CMC/jTs). Finally, the reaction mixture was gel-filtered and the macro-molecular fractions, when displayed the characteristic absorption of 260 nm of the nucleic bases, were collected. 

The N-3 position of uracil also can be modified with carbodiimide reagents. In particular, the water-soluble carbodiimide CMC [l-cyclohexyl-3-(2-morpholinoethyl) carbodiimide, as the metho p-toluene sulfonate salt] can react with the N-3 nitrogen at pH 8 to give an unstable, charged adduct. The derivative is reversible at pH 10.5, regenerating the original nucleic acid base (Figure 1.47). Cytosine is unreactive in this process. 

These compounds are named as cycloalkylalkanes. Examples are dicyclohexylmethane, 1,5-dicyclopenfylpentane, l-cyclohexyl-3-(2-methylcyclohexyl)propane. 

S,3f ,4.S )-2-f(Dimethylaminocarbonyl-phenylalanyl-histidyl)amino]-l-cyclohexyl-3,4-dihydroxy-6-methylheptane (24) 421... 

Isoureoyl Fluoride l-Cyclohexyl-3-trifluoromethyl- E10b2. 114 (Educt)... 

Bis-[pentafluoro-ethyl]-ainino)-tetrafluoro-cthyl]-octafluoro-E10b2. 417 (Educt) l-Cyclohexyl-3,4-difluoro- ElOa, 590 (20 —SO, —R - 2F)... 

A good source of uncommon bases is tRNA. It provides substrates for studying the effect of base on the rate of hydrolysis. Baev et al. (62) showed that V2-dimethylguanylyl-(3 -5 )-cytidine-3 phosphate (G2m-pCp) was hydrolyzed much slower than the usual GpCp. Venkstern (63) reported that Tp was hydrolyzed very slowly. Naylor et al. (64) found that Cp was hydrolyzed with half the rate of CpU. The same group of workers introduced (64, 65) a chemical block on uridine and pseudo-uridine residues by reacting RNA with l-cyclohexyl-3-(2-morpho-liny]-(4)-ethyl)-carbodiimide metho-p-toluene sulfonate. The modification of the uridine residues completely blocked the action of venom exonuclease and also blocked the action of pancreatic RNase. 

As a,a-trehalose lacks a reducing terminal, Gensler and Alam prepared the 6-(p-aminobenzoate) and the 6,6 -bis(p-aminobenzoate), which were coupled to BSA in water by using l-cyclohexyl-3-(2-mor-... 

Table 2.2. lists activators used less commonly for Moffatt oxidations. The following activators, namely diphosgene,262 triphosgene,263 2-chloro-1,3-dimethylimidazolinium chloride,264 l-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metho-p-toluenesulfonate,265 triphenylphosphine dibromide and dichloride,266 and phenyl dichlorophosphate,267 have been the subject of scientific monographs, in which they are proposed as suitable and convenient alternatives to more routinely used activators, and can offer improved oxidation conditions in some substrates. 

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