2-Amino-l-cyclohexyl

Producing of H-L-(4-thiazolyl)Ala amide of (2S,3R,4S)-2-amino-l-cyclohexyl-3,4-dihydroxy-6-methylheptane ... 

Trifluoroacetic acid (50 ml) was slowly added via cannula to a solution of the Boc-L-(4-thiazolyl)Ala amide of (2S,3R,4S)-2-amino-l-cyclohexyl-3,4-dihydroxy-6-methylheptane (6.27 g, 12.6 mmol) in methylene chloride (50 ml) at 0°C. The reaction was stirred 3 h at 0°C and concentrated in vacuum (40°C bath) to an oil which was basified to pH 10-11 with aqueous K2C03. 

To the (2S)-2-benzyl-3-(l-methylpiperatin-4-ylsulfonyl)propionic acid (1.0 g, 3.064 mmol), the H-L-(4-thiazolyl)Ala amide of (2S,3R,4S)-2-amino-l-cyclohexyl-3,4-dihydroxy-6-methylheptane (1.11 g, 2.792 mmol), and 1-hydroxybenzotriazole (1.022 g, 7.563 mmol) in dimethylformamide (20 ml) was added N-methylmorpholine (0.35 ml, 3.2 mmol). The mixture was cooled to -23°C and treated with l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.760 g, 3.96 mmol). After 2 h at -23°C and 14 h at room temperature, the reaction was poured into saturated NaHC03 solution (100 ml) and extracted into ethyl acetate (2x50 ml) which was washed with water (2x50 ml) and brine (50 ml) and then was dried over Na2S04 and evaporated to afford 1.94 g. Recrystallization from ethanol (15 ml)/hexane (90 ml) afforded 1.55g (79%) of (2S)-2-benzyl-3-(l-methylpiperazin-4-ylsulfonyl)propionyl-(L)-(4-thiazolyl)Ala-amide of (2S,3R,4S)-2-amino-l-cyclohexyl-3,4-dihydroxy-6-methylheptane as a white solid, melting point 169°-170°C. 

It was subsequently demonstrated that the formation of C-AIR (107) from AIR (106) required only bicarbonate and that an enzyme was unnecessary [67CC799 71JCS(C)1501]. A more detailed study of the carboxylation was undertaken using the model compound 5-amino-1-cyclohexylimidazole (96 R1 = cyclohexyl, R2 = H) [67CC799 71JCS(C)-1501]. It was found that the best yield (40%) of carboxylated compound (99 R1 = cyclohexyl, R2 = H) was obtained by treatment of the aminoimid-azole (96 R = cyclohexyl, R2 = H) with an saturated aqueous solution of potassium bicarbonate at 70°C for 15 min. Similar results were obtained for the carboxylation of 5-amino-l-cyclohexyl-2-methylimidazole (96 R = cyclohexyl, R2 = Me) to the corresponding carboxylic acid (99 ... 

Substituted (ethyl, -propyl, benzyl), cyclohexyl, 2-furyl, and 2-thienyl) 2-amino-l,3,4-thiadiazoles 451 react with a-bromoarylketones to give imidazo[2,l- ][l,3,4]thiadiazoles 161 in good yields (Equation 103) (Table 59) <2006BMC3069, 2006TL2811>. 

S,3f ,4.S )-2-f(Dimethylaminocarbonyl-phenylalanyl-histidyl)amino]-l-cyclohexyl-3,4-dihydroxy-6-methylheptane (24) 421... 

Ethyl 4-amino-l-cyclohexyl-2-oxo-l, 2-dihydro-1,8-naphthyridine-3-carboxylate 172-175 612... 

Propan 2,2-Dichlor-l-cyclohexyl-amino- E16d, 801 (Aminochlorie-rung)... 

Hexyl- E19a, 578 (En + Amin) Propan l-Amino-l-cyclohexyl-2,2-... 

Amino-3-(3-cyclohexenyl)-1 -methyl- 442 5-Amino-l-cyclohexyl- 484 5-Amino-4-decyl-1 -(2-pyrimidyl)- 442 3-Amino-l,4-diaryl- 448 3-Amino-l-(2,4-dichlor-benzyl)-4,5-dicyan- 604 5-Amino-l-(2,4-dichlor-benzyl)-4-hydrazinocarb-onyl- 685... 

Amino-l-anilino-1-phenyl- 128 2-Amino- 1-cyclohexylamino- 129 2-Amino- 1-cyclohexyl- 1-f l-(2-amino-athyl)-cyclohexyl]- 138 2-Amino-1,1-diathoxy- 419, 457 2-Amino- 1-dialkylamino-... 

Isopropyl-benzyl- 228 Isopropyl-benzyliden- 228 Isopropy -(2-chlor-phenyl)- 452 Isopropyl-cyclopropyl- 443 (4-Methoxy-phenyl)-benzyl- 228 (4-Methoxy-phenyl)-benzyliden- 228 (4-Methoxy-phenyl)-(2-nitro-benzyliden)- 607 Methyl- 450, 466, 469 Methyl-) 2- amino-athyl)-benzyl- 122 Methyl-(2-amino-athyl)-cyclohexyl- 132 Methyl-(2-amino-athyl)-cyclopentyl- 132 Methyl-(2-amino-athyl)-propyl- 132 (2-Methylamino-propyl)-cyclopropy]-benzyJ- 452 Methyl-) 2-( 3-amino-propyloxy)-athyl]-benzyl- 135 Methyl-)2-(3-amino-propyloxy)-athy]]-(subst.-benzyl)- 135 Methyl-benzyl- 228, 230 Methyl-benzyliden- 228, 230 (2-Methyl-butyl)-(2,4,6-tribrom-phenyl)- 729 Methyl-cyclohexyl- 418 (l-Methyl-cyclohexyl)-benzyliden- 228 Methyl-diathyl- 493, 674 Methyl-diphenyl- 706 Methyl-(2-nitro-phenyl)-benzoyl- 470 Methyl-phenyl-acetyl- 671 (4-Methyl-phenyl)-benzyliden- 228 Methyl-phenyl-cyclohexylcarbonyl- 646 Methyl-phenyl-hexanoyl- 646 (4-Methyl-phenyl)-(2-nitro-benzyliden)- 607 Methyl-) l-phenyl-propyl-(2)]-... 

Isocyanide, benzyl, 55, 98 Isocyanide, butyl-, 55, 98 Isocyanide, cyclohexyl-, 55, 98 ISOCYANIDE, 1,1-dimethylethyl- [Isocy-amde, tert-butyl-], 55,96 Isocyanide, dodecanyl- 55,98 Isocyanide, ethyl- 55,98 Isocyanide, methyl-, 55, 98 Isocyanide, phenyl-, 55, 98 1//Isoindole 1,3(2//) dione, 2 amino [Phthahmidc, N-amino-], 55, 115 1//-ISOINDOLE-1,3(2//)-DIONE, trans-( )-2-(2,3-diphenyl-l-aziridinvl)-[Azindine, frans-2,3-diphenyl-l-phthalimido-], 55, 115 ISOXAZOLE, 3-(4-chlorophenyl)-5-(4-methoxy phenyl)-, 55, 39 Isoxazole 5-(4-chlorophenyl)-3-(4-meth-oxyphenyl)-, 55, 42... 

By the same procedure, crystalline picrates of 5-amino- 1-cyclohexyl-2-methylimidazole (112 R = Me) (45%) [71JCS(C)1501] and 5-amino-l-(2-pyridyl) imidazole (96 R1 = pyrid-2-yl, R2 = H) (20%) [80JCS(P1)2316] were obtained from the sodium salts of the corresponding acids. 

Hohe optische Ausbeuten an 2-Amino-alkanen [z.B. (S)-2-Amino-butan, (S)-l-Amino-1-cyclohexyl-ethan] und Amino-ary 1-alkanen [z.B. (S)-i- und (S)-2-Amino-1-phenyl-propan] erhalt man auch bei der Reduktion der entsprechenden Ketoxime mit einem aus Lithium-alanat und 3-0-Cyclohexylmethyl-l,2-0-cyclohexyliden-a-D-glucofuranose ge-bildeten Komplex in Ether3. 

Chemical Name 1-Propanone, l-cyclohexyl-3-((2-hydroxy-l-methyl-2-phenylethyl)amino)-, (R-(R, S ))-, hydrochloride... 

Chloro-2-cyclohexyl-6-nitroisoindolin-l-one (93.9 g) was reduced in concentrated hydrochloric acid (1,970 ml) with stannous chloride (376 g). The reaction temperature rose to 70°C. The resulting solution was cooled in ice and filtered. The product was washed well with water, filtered and dried to give 6-amino-5-chloro-2-cyclohexylisoindolin-l-one (74.1 g, 87.6%) which, after recrystallization from benzene, had a MP of 216°C to 218°C. 

The decomposition or retro aldol condensation of 2-nitro alcohols, as described in Scheme 9.2, has often been observed in the hydrogenation over Raney Ni in neutral or basic medium. The hydrogenation of (1-nitro-l-cyclohexyl)(4-pyridyl)methanol (7) over Raney Ni in ethanol gave a mixture of 4-hydroxymethylpyridine and cyclo-hexylamine in 73% yield, although 2-nitro-l-(4-pyridyl)ethanol (8) gave the undecomposed amino alcohol in 70% yield (Scheme 9.3).15 The presence of carbon... 

Addition of cyclohexyl isocyanide to 4-amino-l-chroma-l,3-dienes ( )-96b-e provides a mild and regiospecific access to l,4-diamino-2-ethoxy naphthalenes 104 [l-NHc-QHn 4-NRR1 = NMe2, (S)-2-hydroxymethyl-pyrrolidinyl, (lf ,25)-2-methylamino-l-phenyl-l-propanol, N-f-BuMe] in... 

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