Kuhn. Roland

Malcolm MacCoss, Christopher J. Swain, Timothy Harrison, Raymond G. Hill, Franz Hefti, Edward M. Scolnick, Margaret A. Casderi, Gary G. Chicchi, Sharon Sadowski, Angela R. Williams, Louise Hewson, David Smith, Emma J. Carlson, Richard J. Hargreaves and Nadia M. J. Rupniak, Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors , Science 281 (1998) 1640-45 Kuhn, Roland, Artistic Imagination and the Discovery of Antidepressants , Journal of Psychopharmacology 4, no. 3 (1990) 127-30... 

There was a problem with this first version of the biochemical theory of depression. Iproniazid was not the only drug that had been reported to be effective as an antidepressant. Imipramine, the drug that had been tested by the Swiss psychiatrist Roland Kuhn, seemed to have similar effects. But imipramine is not an MAOI it does not inhibit the destruction of neurotransmitters in the synapse. So if antidepressants worked by inhibiting monoamine oxidase, why was imipramine effective How could its apparent effectiveness be reconciled with the chemical-imbalance theory ... 

Names associated in these discoveries include Roland Kuhn and John Cade. While looking for a treatment for depression, Kuhn worked with thorazine, the newly found drug effective with schizophrenia. He progressed to find the second classification of antidepres-... 

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