Knockout stroke

Knockout stroke—maximum distance in inches for knockout system. 

The maximum knockout stroke determines the movement available for ejection. 

Synaptic stimulation, ischemia or seizure activates phospholipase A2 and releases arachidonic and docosahexaenoic acids. Ischemia or seizure triggers accumulation of free AA, DHA and other FFA in the brain( see also Chs 32, 37). This reflects PLA2 activation in excitable membranes [24]. While little is known about the mechanisms that control its activity, the importance of cPLA2 in ischemic brain injury is strongly supported by the recent finding that cPLA2-knockout mice have substantially reduced infarcts and neurologic deficits in a model of stroke [25],... 

Estrogens are also neuroprotective against ischemic damage [13], and aromatization of androgens to estrogens plays a role even in females, where knockout of the aromatase gene increases the vulnerability of female mice to stroke damage by a process that is prevented by estradiol administration [33]. 

Clemens, J. A., Stephenson, D. T., Smalstig, E. B., Dixon, E. R, and Little, S. P. (1997). Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats. Stroke 28, 1073-1080. Crack, P. J., Taylor, J. M., Ali, U., Mansell, A., and Hertzog, P. J. (2006). Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury. Stroke 37, 1533-1538. 

The development of genetically manipulated laboratory mice deficient in or overexpressing enzymes/proteins in the free radical pathways has allowed substantial progress to be made in stroke research. An example is knockout (KO) mice with targeted disruption of the inducible SOD (Mn-SOD or SOD2). The development of these animals has provided a model for studying the effects of free radicals by perturb-... 

Ejector Pins. Ejector pins are mounted on an ejector plate and extend through the mold to the core or cavity molding surface. The pins are activated by the movement of the ejector plate, which is tied in with the injection press knockout system. When the mold opens (normally during the last part of mold opening, or stroke), the ejector plate pushes the ejector pins forward, extending them through the mold, thus forcing the part off the core or out of the cavity. 

---