Kinase-dependent cell growth

Kinase-dependent cell growth BaF3 Cell number or metabolism measured by standard cell detection methods such as ATP detection or MTT dye, Alamar blue cell growth dependent upon specific tyrosine kinase Very high-throughput cell-based assay Limited for use with tyrosine kinases cell line must be made Warmuth (2007)... 

Nojiri H, Stroud MR, Hakomori S A specific type of ganglioside as a modulator of insulin-dependent cell growth and insulin receptor tyrosine kinase activity Possible association of ganglioside-induced inhibition of insulin receptor function and monocytic differentiation induction in HL60 cells. J. Biol. Chem. 1991 266 4531-4537. 

EGF-dependent receptor tyrosine kinase and cell growth... 

Figure 3 Phosphorylation-dependent viral growth. In the presence of Li+-dependent kinases, viruses are replicating and ultimately lead to cell death (top). When the Li+-dependent kinases are inhibited, the virus no longer replicates and the cell undergoes normal functions like mitosis.

Miyake, S., K. P. Mullane-Robinson, N. L. Lill, P. Douillard, and H. Band. Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem. 274 16619-28.1999. 

Wang Q, Worland PJ, Clark JL, Carlson BA, Sausville EA (1995) Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cy-clin-dependent kinases 1 and 2. Cell Growth Differ 6 927-936 Wang J, Walsh K (1996) Resistance to apoptosis conferred by CDK inhibiors during myocyte differentiation. Science 273 359-361 Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O Connor PM (1996) UCN-01 a potent abrogator of G1 checkpoint function in cancer cells with disrupted P53. J Natl Cancer Inst 88 956-965... 

Wang, S. L., Ribar, T. J. and Means, A. R., 2001, Expression of Ca2- -/calmodulin-dependent protein kinase IV (CaMKIV) messenger RNA during murine embryogenesis, Cell Growth Differ, 12, pp 351-361. 

GTPs and EGCG in particular are able to activate a pathway for cell differentiation in normal human epidermal keritinocytes (NHEKs). In contrast to tumor cells, NHEKs undergo accelerated differentiation when exposed to EGCG, which is associated with induction of p57/KIP2, a cyclin-dependent kinase inhibitor involved in cell growth and differentiation [1,15]. 

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