Seborrheic keratosis

The stratum corneum consists of denucleated corneocytes filled with cross-linked proteins, while the intercellular space is occupied by lipids synthesized prior to and during cornification [24], Formation of this barrier relies on the cornification of epidermal keratinocytes, which undergo growth arrest, terminal differentiation, and an epidermal-specific cell death, referred to as planned cell death [25], Abnormalities in any of these programmed events may lead to epidermal disorders such as psoriasis, atopic dermatitis, and cancer. Flowever, biological events that enable basal cells (stem cells) to proliferate, differentiate, and commit planned cell death are still poorly understood [10]. The keratinocyte differentiation process can be stimulated by prodifferentiation agents such as extracellular calcium and 1,25-dihydroxy cholecalciferol (referred to as vitamin D3 hereafter) [23], Aberrant or absent differentiation can be found in other skin disorders such as atopic keratosis, seborrheic keratosis, and rosacea. 

Epidermal growths such as actinic keratosis, lentigines or thin seborrheic keratoses can all be treated effectively with 25-35% TCA peels. Thicker epidermal growths or growths involving the dermis will be more resistant to treatment such as hypertrophic actinic keratoses and thicker seborrheic keratoses and may even be resistant to a medium-depth peel. Resistant lesions many times are best treated with a combination of a medium-depth chemical peel and other modalities such as manual dermasanding or CO, laser. 

K4. Kint, A., Histophotometric investigation of the nuclear DNA-content in normal epidermis, seborrheic keratosis, keratosis senilis, squamous cell carcinoma and basal ceU carcinoma. J. Invest. Dermatol. 40, 95 (1963). 

Shimizu N, Ito M, Tazawa T, et al. Immunohistochemical study of keratin expression in certain cutaneous epithelial neoplasms. Basal cell carcinoma, pilomatricoma, and seborrheic keratosis. Am J Dermatopathol. 1989 11 534-540. 

Bai H, Cviko A, Granter S, et al. Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. Hum Pathol. 2003 34 559-564. 

Bagheri MM, Alagheband M, Memar OM, Eiler DB (2002) Pemphigus foliaceus presenting as eruptive seborrheic keratosis and responding to oral gold treatment. J Drug Dermatol, 1 333-334. 

Figure 5. Upper figure R(V representations ofskin with basal cell carcinoma, BCC (thinner line) and seborrheic keratosis, SK (thicker line). Lower figure The difference between the two curves in the upper figure (thicker line) and pure liquid water smoothed with a Savitzky-Golay 9 points smoothing function (thinner line). Adapted from Journal of Molecular Structure, 661-662, M. Gniadecka, O.F. Nielsen, H.C. Wulf Water content and structure in malignant and benign skin tumours, 405-410 Copyright 2003, reference 26, with...

This chapter will review the use of AHA peels—in particular, glycolic acid peels [GAP)—in the treatment of the signs of photoaging, acne, melasma, lentigines and seborrheic keratosis, keratosis pilaris, and warts. Furthermore, GAP can be used in combination with fluorouracil to treat pre skin cancer conditions, such as actinic keratosis and actinic cheilitis. 

Glycolic acid peels are used as adjunctive treatments in conditions such as acne, postinflammatory hyperpigmentation usually resulting from acne, shallow acne scars, papulopustular rosacea, melasma, seborrheic and actinic keratoses, keratosis pilaris, and some warts resistant to conventional treatments. 

Figure 8.25 Sixty-five-year-old Caucasian Fitzpatrick II skin type. (A) Pre 2-minute Stone VK, 4-minute Stone II, tape and powder (B) oblique view showing multiple actinic keratosis and seborrheic keratosis ...

A 70-year-old female with solar lentigines, seborrheic keratosis, and rhytides is shown at baseline and at 2 months after a full face 25% Obagi s blue peel (Fig. 11.6). The seborrheic keratosis were treated with light elec-... 

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