Kelsey

R. G. Craig, iu B. R. Land and C. C. Kelsey, eds., Internationa/Prosthodontics Workshop on Comp/ete Denture Occ/usion, University of Michigan Press, Ann... 

Phenol Coefficient Test. The first important attempt at standardizing testing methods was known as the phenol coefficient test (96). It has been modified several times, and is an official AO AC screening test recognized by EPA and PDA. The phenol coefficient test compares the activity of disinfectants to that of phenol, under specific conditions, to give a number that measures the activity of the chemical tested with respect to that of phenol, ie, the phenol coefficient. The AO AC method employs visual examination of bacterial growth in a nutrient medium. The Kelsey-Sykes test (1969) is a modified method popular in British circles. 

Much work has also 4)een done bearing directly or indirectly on the mode of action of quinine and other anti-malarial drugs. The absorption, distribution and metabolism of quinine has been investigated by various workers of whom Kelsey, Ceiling, Oldham and Dearborn (1944)... 

EtOH) was examined in detail by Mead and Koepfli, who, from its reactions and the resemblance of its absorption spectrum to that of 2-hydroxy-6-methoxy-4-methylquinoline, regard it as Z-2 -hydroxyquinine (2 -hydroxy-6 -methoxy-3-vinylruban-9-ol). According to P. B. Marshall, this metabolite is inactive in chick malaria, but Kelsey efaZ. (1946) find that at a dosage of 40-70 mgm./kilo./day, it exercises about the same degree of suppression as 15 mgm./kilo./day of quinine, and quote E. K. Marshall for the observation that it has about one-twentieth the activity of quinine in the malaria of ducks. 

Kelsey et al. reported that die cyclic ketal of 4,4,-dihydroxybenzophenone (DHBP) can polymerize with 4,4,-difluorobenzophenone in DMAc at 150°C (Scheme 6.16).85 The polymerization afforded soluble amorphous polyketal that was quantitatively converted to PEK. Because of relatively lower reaction temperature, the PEK had minimal defect structures and thus possesses higher crystallinity and higher Tg, and has better physical properties than its counterpart made under higher temperatures. 

Kelsey and Bergman (174) have examined the stereochemistry of solvolysis of cis- 179a, and fra s-l-cyclopropyl-1-iodopropenes, 179b. 

The Kelsey-Sykes (KS) test. Having regard to the many disadvantages alleged against the RW and CM tests, attempts were made and published in the early 1960s to find improved test methods. The foundations for the new test were laid by Kelsey et al. in 1965, and with the collaboration of the late G. Sykes and ofisobel M. Maurer, the Kelsey-Sykes test was evolved. This test embodied several principles. Firstly, it was a capacity test. Here a bacterial inoculum was added to the disinfectant in three successive lots at 0, 1 and 5 minutes. This is the principle of a capacity test where the capacity or lack of capacity ofthe disinfectant to destroy successive additions of a bacterial culture is tested. 

This account highlights the main features of the test. It is described in detail by Kelsey and Maurer (1974). 

Cowen R.A. (1978) Kelsey-Sykes capacity test a critical review. PharmJ, 220, 202-204. 

Croshaw B. (1981) Disinfectant testing—with particular reference to the Rideal-Walker and Kelsey-Sykes tests. In Disinfectants Their Use and Evaluation of Effectiveness (eds C.H. Collins, M.C. Allwood, S.F. Bloomfield A. Fox), pp. 1-15. London Academic Press. 

Kelsey J.C. Maurer I.M. (1974) An improved Kelsey-Sykes test for disinfectants. Pharm J, 207, 528-530. 

Likewise, the related zeolite mineral clinoptolite is an active stimulant of macrophage chemiluminescence (Velichkovsky et al., 1983). Evidence of the genotoxic and clastogenic activity of erionite to cultured cells has also been presented (Poole et al., 1983 Kelsey et al., 1986). 

Boyle, C. A., Berkowitz, G. S., LiVolsi, V. A., Ort, S., Merino, J. J., White, C., Kelsey, J. L., Caffeine consumption and fibro cystic breast disease in a case control epidemiologic study, J Natl Cancer Inst, 72, 1015, 1984. 

Schedl, A., Montoliu, L., Kelsey, G., and Schiitz, G. (1993). Ayeast artificial chromosome confers copy number-dependent expression in transgenic mice. Nature 362 258-260. 

Ankeny, M.D., Coons, L.M., Majumdar, N., Kelsey, J., and Miller, M., Performance and cost considerations for landfill caps in semi-arid climates, in Landfill Capping in the Semi-Arid West Problems, Perspectives, and Solutions, Reynolds, T.D. and Morris, R.C., Eds, Environmental Science and Research Foundation, Idaho Falls, ID, 1997. 

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