Keeler

R. F. Keeler and co-workers. Bull Environ. Contam. Toxicol 15, 522 (1976). 

A. A. Seawright, M. P. Hegarty, L. F. James and R. F. Keeler, Plant Toxicology, Queensland Dept of Primary Industries, Yeerongpilly, Australia, 1985. 

Q. Johnson and A. Mitchell, R.N. Keeler, and L. Evans, X-Ray Diffraction During Shock-Wave Compression, Phys. Rev. Lett. 25, 1099-1101 (1970). 

K01 R.N. Keeler, in Proceedings of the International School of Physics Enrico... 

A formidable array of compounds of diverse structure that are toxic to invertebrates or vertebrates or both have been isolated from plants. They are predominately of lipophilic character. Some examples are given in Figure 1.1. Many of the compounds produced by plants known to be toxic to animals are described in Harborne and Baxter (1993) Harborne, Baxter, and Moss (1996) Frohne and Pfander (2006) D Mello, Duffus, and Duffus (1991) and Keeler and Tu (1983). The development of new pesticides using some of these compounds as models has been reviewed by Copping and Menn (2000), and Copping and Duke (2007). Information about the mode of action of some of them are given in Table 1.1, noting cases where human-made pesticides act in a similar way. 

Keeler, R.F. and Tu, A.T. (Eds.) (1983). Handbook of Natural Toxins Vol 1 Plant and Eungal Toxins. New York Marcel Dekker. 

The authors are grateful to J. E. Bourne, P. A. Keeler, and R. W. Lisowe for their assistance in all aspects of this study. 

Hartman, E., Keeler, K., and Kowalski, J. K., Layered Neural Networks with Gaussian hidden rmits as uttiversal approximators. Neural Comput. 2, 210 (1990). 

Thrippleton, M.., Keeler,. Elimination of zero-quanmm interference in two-dimensional NMR spectra. Angew. Chem. Int. Ed. 2003, 42, 3938-3941. 

Titman, J. J., Keeler, J. Measurement of homonuclear coupling constants from NMR correlation spectra. J. Magn. Reson. 1990, 89, 640-646. 

Keeler GJ, Glinsom G, Pirrone N. 1995. Particulate mercury in the atmosphere its significance, transport, transformation and sources. Water Air Soil Pollut 80 159-168. 

Landis MS, Vette AF, Keeler GJ. 2002. Atmospheric mercury in the Lake Michigan Basin influence of the Chicago/Gary urban area. Environ Sci Technol 36(13) 3000-3009. 

Rea AW, Lindberg SE, Keeler GJ. 2001. Dry deposition and foliar leaching of mercury and selected trace elements in deciduous forest throughfall. Atmos Environ 35 1352-2310. 

Atkeson T, Axelrad D, Pollman C, Keeler G. 2003. Integrating atmospheric mercury deposition and aquatic cycling in the Florida Everglades an approach for conducting a total maximum daily load analysis for an atmospherically derived pollutant. Tallahassee (FL) Florida Department of Environmental Protection (FDEP) (http //www. floridadep.org/labs/mercury/index.htm). 

Duever, T.A., S. E. Keeler, P.M. Reilly, J.H. Vera, and P.A. Williams, "An Application of the Error-In-Variables Model-Parameter Estimation from van Ness-type Vapour-Liqud Equilibrium Experiments", Chem. Eng Sci., 42, 403-412 (1987). 

Breci, L., Hattrup, E., Keeler, M., Letarte, J., Johnson, R., Haynes, PA. (2005). Comprehensive proteomics in yeast using chromatographic fractionation, gas phase fractionation, protein gel electrophoresis, and isoelectric focusing. Proteomics 5, 2018-2028. 

Cannabinoids appear to have a very complex interaction with seizure activity, exerting both anticonvulsant and proconvulsant effects. Anecdotal testimonies abound (Grinspoon and Bakalar, 1993), but there has been very little controlled human research. In single-case studies both use and withdrawal of marijuana have been linked to the resumption of seizures (Keeler and Reifler, 1967 Consroe et al., 1975). In a randomised placebo-controlled blind study, patients who responded poorly to standard treatments experienced improved seizure control in response to cannabidiol administration. Cannabidiol does not interact with cannabinoid receptors, and animal studies indicate that it has different anticonvulsant effects to other cannabinoids (Cunha et al., 1980). As such it may prove to have useful therapeutic properties. 

Keeler MH and Reifler CB (1967). Grand mal convulsions subsequent to marijuana use. Diseases of the Nervous System, 18, 474-475. 

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