IV bolus

Clinical Use. Vancomycin and teicoplanin as fomiulated dmgs are lyophilized powders to be reconstituted with sterile water for injection. Vancomycin hydrochloride [1404-93-9] is presented in vials of 500 mg that give 100—200 mL solution of pH 2.5—4.2. It is administered by slow (60 min) infusion at a dose of 500 mg every 6 h or 1 g every 12 h/d. The teicoplanin contains the five factors (87%) plus 13% of the pseudoaglycone T-A3-1. It is presented in vials containing 200 mg of lyophili ed power that after dissolution with 3 mL of solvent gives a solution at pH 7.5. The dose regimen is 200—800 mg/d by iv bolus adrninistration. 

Adenosine is not active orally, but adrninistered as an iv bolus dmg adenosine rapidly eliminates supraventricular tachycardias within 1—2 min after dosing. The dmg slows conduction through the AV node. Adenosine is rapidly removed from the circulation by uptake into red blood ceUs and vascular endothehal ceUs. Thus the plasma half-life is less than 10 s. Adenosine is rapidly metabolized to inosine or adenosine monophosphate and becomes part of the body pool for synthesis of adenosine-triphosphate. 

Hypertonic Reduces brain water 23.4% NaCl IV bolus over Serum Na, Osm Do not Renal failure... 

Barbiturates metabolic demand dose as 500 mg IV bolus CPP >60 using hypotension. 

Consider glucagon 2-10 mg IV bolus followed by a 2-10 mg/h continuous IV infusion in P-adrenergic blocker or calcium channel blocker-induced bradycardia not responsive to atropine... 

Nesiritide—2 mcg/kg IV bolus followed by a continuous IV infusion of 0.01 mcg/kg/min. Doses above the initial infusion rate should be limited to carefully selected patients. High-alert medication—read package insert before use... 

Prepare 100 units of insulin in 100 mL normal saline ° 10 units or 0.1 units/kg IV bolus, then 0.05-0.1 units/kg/h continuous IV infusion... 

Liothyronine (T3) 25-50 meg IV bolus. Use 10-20 meg IV bolus in patients with CAD. Subsequent doses (e.g., 2.5-10 meg IV q6-8h) should be administered between 4—12 h after the initial bolus dose and continued until signs and symptoms resolve... 

Breakthrough seizure, 50 mg IV bolus, then increase the rate by 0.5-1 mg/kg/h... 

If breakthrough seizure, 50 mg IV bolus and increase infusion to closest preseizure dose... 

Labetalol hydrochloride 20-80 mg IV bolus every 10 minutes 5-10 minutes 3-6 hours Vomiting, scalp tingling, dizziness, bronchoconstriction, nausea, heart block, orthostatic hypotension Most hypertensive emergencies except acute heart failure... 

Esmolol hydrochloride 250-500 mcg/kg/minute IV bolus, then 50-100 mcg/kg/minute by infusion may repeat bolus after 5 minutes or increase infusion to 300 mcg/minute 1-2 minutes 10-30 minutes Hypotension, nausea, asthma, first-degree heart block, heart failure Aortic dissection, perioperative... 

Phentolamine 5-1 5 mg IV bolus 1-2 minutes 10-30 minutes Tachycardia flushing, headache Catecholamine excess... 

For STSE ACS administer 60 units/kg IV bolus (maximum 4000 units) followed by a constant IV infusion at 12 units/kg/hour (maximum 1000 units/hour)... 

Administer 30 mg IV bolus for STE ACS patients age less than 75 years... 

Lidocaine 0.5-0.75 mg/kg IV bolus Repeat every 5-10 minutes to a total of 3 mg/kg 1-4 mg/minute continuous infusion... 

SC administration 1 7,500 units given every 12 hours (an initial 5000 unit IV bolus dose is recommended to obtain rapid... 

Midazolam (Versed) 0.2 mg/kg IV bolus followed by 0.05-0.6 mg/kg per hour continuous infusion Bolus dose may also be given intranasally, buccally, or intramuscularly... 

Cyclophosphamide 600 mg/m2 IV, day 1 Methotrexate 40 mg/m2 IV, day 1 Fluorouracil 600 mg/m2 IV, days 1 and 8 Repeat cycles every 28 days for 6 cycles Dose-dense AC —> paclitaxel Doxorubicin 60 mg/m2 IV bolus, day 1 Cyclophosphamide 600 mg/m2 IV, day 1 Repeat cycles every 14 days for 4 cycles (must be given with growth factor support) Followed by ... 

Docetaxel + capecitabine Docetaxel 75 mg/m2 IV over 1 hour, day 1 Capecitabine 2000-2500 mg/m2 per day orally divided twice daily for 14 days Repeat cycles every 21 days Epirubicin + docetaxel" Epirubicin 70-90 mg/m2 IV bolus Followed by Docetaxel 70-90 mg/m2 IV over 1 hour Repeat cycles every 21 daysv Doxorubicin + docetaxel" Doxorubicin 50 mg/m2 IV bolus, day 1 Followed by Docetaxel 75 mg/m2 IV over 1 hour, day 1 Repeat cycles every 21 days"... 

FOLFIRI Irinotecan 1 80 mg/m2 IV day 1 Folinic acid (leucovorin) 200 mg/m2 IV day 1 5-Fluorouracil 400-500 mg/m2 IV bolus, after folinic acid then 2400-3000 mg/m2 of 5-fluorouracil IV over 46 hours Repeat every 14 days... 

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