Issue Investigation and Practices in Discovery Toxicology

Dolores Diaz Dylan P. Hartley and Raymond Kemper  

During the early stages of drug discovery, prior to the availability of the first chemical matter (hit-to-lead phase). 

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Yvonne Will, J. Eric McDufSe, Andrew J. Olaharski, and Brandon D. Jefiy. 

Zabkaetal., 2015), and (ii) the use of similar models to determine the lack of T1 for the intestinal toxicity caused by tankyrase inhibitors (Zhong et al., 2013). 

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