Daidzein Daidzin

Daidzcin H H OH 7-O-glucosidc of daidzein = Daidzin of genistein = Genistin of glycitein = Glycrtm HO ... 

Securinega suffructicosa Securinine Sesamum indicum Silybium marianum Silymarin Taxifolin Sophora flavescens Sphocar dipine Soybean isoflavones Daidzein Daidzin Genistein Genistin Glycitein Glyzitin... 

Genistin, genistein, daidzein, daidzin, glycitin, glycitein, ononin, formononetin, sissotrin, biochanin A... 

Recently, some of the specific faecal bacteria involved in the metabolism of dietary isoflavonoids were isolated (Hur et al., 2000). They have been shown to selectively convert genistin and daidzin to their respective aglycones. One of the isolated bacteria, under anoxic conditions, was further shown to metabolise genistein and daidzein to their respective dihydroxy-genistein and dihydroxy-daidzein. In the case of lignans, enterodiol and enterolactone were shown to be excreted in vivo only in rats harbouring a gut microflora (Rowland et al, 1999). 

Isoflavonoids include the isoflavones genistein and daidzein, which occur mainly as the glycosides genistin and daidzin (see Figure 7.2), respectively, in soybeans and consequently in a wide range of soy-derived foods and to a lesser extent in other legumes. Traditional... 

Variety Daidzin Genistin Daidzein Genistein Total Free CYP3A4 inhibition... 

Pueraria lobata (Willd.) Ohwi. P. pseudo-hirsuta Tang. Ge Gen (Kudzu) (root) Isoflavones, daidzin, diadz.in-4, 7-diglucoside, daidzein, puerarin, xylopurarin, robinin, kaempferol-rhamnoside, fatty acids.12-33-48 Antispasmodic, hypotensive, and stabilizing blood pressure, treat angina pectoris. 

Daidzin 7,4 -Dihydroxyisoflavone 7- glucoside or daidzein 7-O-glucoside or daidzein 7-O-p-o-glucopyranoside I X ° /° X... 

Figure 11.6.3 Gradient HPLC separation of isoflavone standards (see Basic Protocol 3). Peaks 1, daidzin 2, glycitin 3, genistin 4, malonyldaidzin 5, malonylglycitin 6, acetyldaidzin 7, acetylglycitin 8, malonylgenistin 9, daidzein 10, glycitein 11, acetylgenistin 12, genistein. Conditions Waters Nova-Pak C18 reversed-phase column (150 x 3.9 mm 4-pm i.d. 60 A pore size) mobile phase 1% acetic acid in water (solvent A) and acetonitrile (solvent B) flow rate 0.60 ml/min UV detector 260 nm column temperature 25°C. The dotted line represents the gradient of solvent B.

Isoflavones are derivatives of the parent compound isoflavone (3-phenylc,hromone 3-phenylbenzopyran-4-one). The dietary isoflavone phytoestrogens (notably from soya bean) that bind to the oestrogen receptor are the best known, namely daidzein (7,4 -dihydroxy-isoflavone), genistein (5,7,4 -trihydroxyisoflavone) and glycitein (7-hydroxy-6-methoxy-isoflavone) and their respective pro-phytoestrogen 7-0-glucoside precursors daidzin,... 

Jones et al. (1989) developed an HPLC-UV (262 nm) method (C18 column) for analysis of phytoestrogens and coumestrol. Ethyl benzoate was used as an internal standard. The recovery rate was from 90% to 105% for daidzin and daidzein. The detection limit was approximately 20 ng based on a signal-to-noise ratio of 3 1. 

Soy Sample Daidzin Cenistin Clycitin Malonyl Daidzin Malonyl Cenistin Malonyl Clycitin Acetyl Daidzin Acetyl Cenistin Acetyl Clycitin Daidzein Cenistein Clycitein... 

Choo, M.K., E.K. Park, H.K. Yoon, and D.H. Kim. 2002. Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. Biol. Pharm. Bull. 25(10) 1328-1332. 

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