Isoflavones accumulation

This increased resistance of LDL to oxidation is in agreement with the findings of a number of studies with dietary soy, including the increase in lag time in a study in six young healthy male and female subjects who consumed three soy bars per day (providing 57 mg total isoflavones/day 36 mg genistein and 21 mg daidzein) for 2 weeks.Although HDL-derived 17(3-estradiol fatty acid esters have been shown to accumulate in LDL ex v/vo and esterified... 

Lens aldose reductase has been implicated in the pathogenesis of cataracts in diabetic and galac-tosemic animals. The enzyme catalyzes the reduction of glucose and galactose to their polyols, which accumulate in large quantities in the lens and ultimately lead to mature lens opacities. Several key bioflavones have activity against this enzyme. Oral administration of quercitrin decreased the accumulation of sobital in the lens. Therefore, the accumulation of lens opacities could be partially abrogated by certain flavonoids. In a study of 30 flavones, 4 isoflavones, and 13 coumarins, many potent inhibitors were found, but 5,7,3, 4 -tetrahydroxy-3,6-dimethoxyflavone and 6,3, 4 -trihy-droxy-5,7,8-trimethoxyflavone were especially active. 

Vaclavikova et al. [216] have investigated the effect of 13 flavonoid derivatives—aurones, chalcones, flavones, flavonols, chromones, and isoflavones—on 14 C-paclitaxel transport in two human breast cancer cell lines, the doxorubicin-resistant NCI/ADR-RES and sensitive MDA-MB-435. The compounds with known binding affinity toward the NBD of P-gp were selected. The four aurones studied most effectively inhibited P-gp-related transport in the resistant fine in comparison with other groups of flavonoids. The aurones also most effectively increased the intracellular accumulation of paclitaxel and decreased its efflux. The results obtained did not always correlate with the binding of flavonoid derivatives to P-gp, so this indicated that the binding was not the only factor influencing the transport of paclitaxel. The different aspects of inhibition of P-gp by polyphenols was recently reviewed by Kitagawa [212],... 

GRAHAM, T.L., KIM, J.E., GRAHAM, M.Y., Role of constitutive isoflavone conjugates on die accumulation of glyceollin in soybeans infected with Phytophthora megasperma Mol. Plant-Microbe Interact., 1990,3,157-166. 

In other experiments, the effects of 16 flavonoids and 5 isoflavones on the drug accumulation were compared in human MDR1 gene-transfected mouse lymphoma cells and MRP-expressing human breast cancer cells. The expression of P-gp 170 and P-gp 190 was confirmed by an immunocytochemical method [14,16]. 

Figure 7.11 (Continued) (f) Occurrence of flavonoids. Key to branches leading to families that accumulate isoflavones isoflavones and pterocarpans catechins/ proanthocyanins. See also legend (a).

Kim, S. M.A. Berhow J. Kim H. Chi S. Lee I. Chung. Evaluation of soyasaponin, isoflavone, protein, lipid, and free sugar accumulation in developing soybean seeds. /. Agric. Food Chem. 

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