Iso-Flavone

SETCHELL K D R and CASSIDY A (1999) Dietary iso flavones Biological effects and relevance to health , JiVuir, 129, 758S-67S. 

JENKINS D J, KENDALL 0 W, CONNELLY P W, JACKSON C J, PARKER T, FAULKNER D and VIDGEN E (2002) Effects of high- and low-iso flavone (ph)itoestrogen) soy foods on inflammatory biomarkers and pro inflammatory c)itokines in middle-aged men and women. Metabolism. 51 (7) 919-24. 

Liu, Q., Sang, W., and Xu, X., Solvent effects on infrared spectra of 5-methyl-7-methoxy-iso-flavone in single solvent systems, J. Mol. Struct., 608, 253, 2002. 

The 13C chemical shifts of the carbonyl resonances of 5,7-dihydroxyflavonoids are characteristic of the different types of flavonoid compounds For flavones and iso-flavones the C-4 resonance generally appears around 181 ppm, for dihydroflavones around 196 ppm and for flavonols around 176 ppm. 

Griffith AP and Collison MW, Improved methods for the extraction and analysis of iso-flavones from soy-containing foods and nutritional supplements by reversed-phase high performance liquid chromatography and liquid chromatography-mass spectrometry. J Chromatogr A 913 397 113 (2001). 

Pinocembrin 7-0-Rha-Glc (= 5,7-Dihydroxyflavone 7-0-Rha-Glc Saratonoside) (flavone O-glycoside) Puerarin (iso flavone)... 

Isoflavones. - An interesting condensation of a benzyl cyanide with a salicylic ester (173) in boiling pjn-idine containing t-butoxide has given 2-aminoiso-flavones (174). Robustigenin (176), which occurs in Derris robusta, has been synthesized from the deoxybenzoin (175). An earlier report that iso-flavone may be synthesized via an enamine has been disputed and the procedure shown to yield 2-morpholino-2/f-isoflavene/ ... 

Aldin, E.A. C.A. Reitmeier PA. Murphy. Bitterness threshold and descriptive analyses of soy iso-flavones and saponins./ FoodSci. 2006, 71, S211-215. 

Penotti, M. E. Fabio A.B. Modena M. Rinaldi U. Omodei P. Vigano. Effect of soy-derived iso-flavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Pertil. Steril. 2003, 79, 1112-1117. 

In conclusion, our data confirm that soy phytoestrogens possess only modest and transitory effect on thyroid hormone values, but, on the other hand, reveal that some thyroid hormone parameters do correlate with actual iso-flavone levels. 

No increase in mammographic breast density and no significant effects were observed on estradiol, follicle-stimulating hormone, or luteinizing hormone levels in a trial of women, ages 49 to 65, taking 44 mg red clover-derived iso-flavones daily for 1 year (Atkinson et al. 2004). 

Kobayashi, M., H. Noguchi, and U. Sankawa Formation of Chalcones and Iso-flavones by Callus Culture of Glycyrrhiza uralensis with Different Production Patterns. Chem. Pharm. Bull. (Japan), 33, 3811 (1985). 

He X-Z, Li W-S, Blount JW, Dixon RA (2008) Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli. Appl Microbiol Biotechnol 80 253-260... 

Isoflavones are synthesized as one group of end-products (iso-flavones) in the phenylpropanoid biosynthetic pathway (Fig. 60.5). They occur in highest levels in the roots, developing seedlings, and seeds of leguminous plants, but are found in lower amounts in leaves, stems, roots, and flowers of older plants. In seeds, they are... 

Lloyd-Davies, H. HUl, J.L. (1989). The effect of diet on the metaboUsm in sheep of the tritiated iso-flavones formononetin andbiochanin A. Australian Journal of Agricultural Research, 40,157-163. 

The use of thallium(i) carbonate in palladium(0)-catalysed couplings was first investigated by Suzuki and coworkers for the preparation of iso-flavones. In the presence of aqueous thallium(i) carbonate, the desired product was formed in a shorter reaction time compared with use of other bases. Under anhydrous conditions the reaction time was increased fourfold, but the yield was only improved from 85% to 91%. In Scheme 20.19, representative examples of the application of thallium(i) carbonate to accelerate the Suzuki crosscoupling reactions are shown. ... 

Yu, X.-H. et al. (2008) Nucleocytoplasmic-localized acyltransferases catalyze the malo-nylation of 7-O-glycosidic (iso)flavones in Medicago truncatula. Plant J. 55, 382-396... 

Ipriflavone (7-isopropyl-3-phenyl-4H-chromen-4-one), a naturally occurring iso-flavone, was reacted with N2H4 x H2O in ethanol (80°C, 90 min) giving rise to a product A in 92% yield. 

Klejdus, B., D. Vitamvasova-Sterbova, and V. Kubafl. 2001. Identification of iso-flavone conjugates in red clover (Trifolium pratense) by liquid chromatography-mass spectrometry after two-dimensional solid-phase extraction. Anal. Chim. Acta 450(l-2) 81-97. 

Nucleic acids (RNA) Polyphenols, phenolic acids Iso-flavones (oestrogens) Artefact amino-acids... 

However, some substances whose presence is not welcomed remain at least in part through all these stages with the main bulk of the protein, owing to their ability to complex with it by hydrogenbonding or by hydrophobic-hydrophobic interaction. These include nucleic acids, polyphenols and phenolic acids, iso-flavones and, possibly, saponins. It must be added that, though there is evidence that some interference with protein utilisation may still occur, these probably do not represent dangerous toxic hazards. 

Rowland IR, Wiseman H, Sanders TAB, Adlercreutz H, and Bowey EA (2000) Interindividual variation in metabolism of soy iso-flavones and lignans Influence of habitual diet on equol production by the gut microflora. Nutrition and Cancer 36 27-32. 

Adam W, Rao PB, Degen HG, Levai A, Patonay T, Saha-Moller CR. Asymmetric Weitz-Scheffer epoxidation of iso-flavones with hydroperoxides mediated by optically active phase-transfer catalysts. J. Org. Chem. 2002 67(l) 259-264. 

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