Irreversible tissue damage

The concentration of t-PA in human blood is 2—5 ng/mL, ie, 2—5 ppb. Plasminogen activation is accelerated in the presence of a clot, but the rate is slow. The dissolution of a clot requites a week or more during normal repair of vascular damage (17). Prevention of irreversible tissue damage during a heart attack requires that a clot, formed by mpture of an atherosclerotic plaque, be dissolved in a matter of hours. This rapid thrombolysis (dissolution of the clot) must be achieved without significant tibrinogenolysis elsewhere in the patient. 

Chloroformates, especially those of low molecular weight, are lachrimators, vesicants, and produce effects similar to those of hydrogen chloride or carboxyhc acid chlorides. They can also irritate the skin and mucous membranes, producing severe bums and possible irreversible tissue damage. 

Short-term exposure limit (STEL) TLV - the eoneentration to whieh it is believed that workers ean be exposed eontinuously for a short period of time without suffering from initation, ehronie or irreversible tissue damage, or nareosis of suffieient degree to inerease the likelihood of aeeidental injury, impair self-reseue or materially reduee work effieieney, and provided that the daily TWA limit is not exeeeded. A STEL is a 15 min TWA exposure whieh should not be exeeeded at any time during the work day even if the TWA is within the TLV. It should not oeeur more than four times per day or without at least one hour between sueeessive exposures. 

Threshold Limit Value Short-Term Exposure Limit (TLV-STEL) was also developed by ACGIH and represents the concentration to which workers can be exposed continuously for a short period of time without suffering from (1) irritation, (2) chronic or irreversible tissue damage, or (3) narcosis of sufficient degree to increase the likelihood of accidental injury, to impair self-rescue, or to materially reduce work efficiency and provided that the daily TLV-TWA is not exceeded. 

Short Term Exposure Limit (STEL) The time weighted average concentration to which workers can be exposed continuously for a short period of time, normally fifteen minutes, without suffering irritation, chronic or irreversible tissue damage, etc,.. 

Dermal corrosion is the production of irreversible tissue damage in the skin following the application of the test substance. ... 

The acute dermal irritation is the study of reversible inflammatory changes in the skin of test animals following the application of a test chemical. Acute dermal corrosion is the study of irreversible tissue damages in the skin following the application of a test chemical. In the evaluation of toxic characteristics of a chemical, determination of the irritant or corrosive effects on mammal skin is an important study step. Information derived from this test indicates the existence of hazards likely to arise from skin exposure to the test chemical. 

Eye irritation is the production of reversible changes in the eye following the application of a test chemical to the anterior surface of the eye. Eye corrosion is the production of irreversible tissue damage in the eye following application of a test chemical to the anterior surface of the eye. 

Eye corrosion The production of an irreversible tissue damage in the eye(s) following the anterior surface contact of a substance or chemical. 

Fiehler J, Foth M, Kucinski T et al. (2002). Severe ADC decreases do not predict irreversible tissue damage in humans. 

Excretion The physiological process in which the chemical or metabolite is eliminated from the body through urine, feces, sweat, or exhaled gas Eye corrosion The production of irreversible tissue damage in the eye following the anterior surface contact of a substance or chemical Eye irritation Production of an irreversible change in the eye Fetotoxic Adverse health effects to the fetus FFDCA Federal Food, Drug, and Cosmetic Act... 

Brief episodes of ischemia/reperfusion delay the development of irreversible tissue damage induced by a subsequent more prolonged ischemic period.74 Apart from the delay in infarct development, ischemic preconditioning also reduces the extent of apoptosis.75 77 The signal transduction cascade of ischemic preconditioning has been discussed in detail elsewhere.71,78... 

Following an acute myocardial infarction and irreversible tissue damage lost tissue is replaced mostly by scar viable myocytes become hypertrophic as part of a compensa-... 

TLV-STEL TLV-STEL is the maximum Short Term Exposure limit to which the average (i.e. not hypersensitive) worker can be exposed without experiencing either irritation, irreversible tissue damage, or narcosis. 

Noncontrast CT. Early ischemic changes on NCCT include loss of gray-white matter differentiation and sulcal effacement. Within the first 6 h after stroke onset, NCCT identifies irreversible tissue damage with relatively high specificity (85%, 95%CI 77-91%) [69]. The... 

Heiss WD, Sobesky J, Hesselmann V (2004) Identifying thresholds for penumbra and irreversible tissue damage. Stroke 35 2671-2674... 

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