Mass spectrometric detection ionization

Barcelo D, Porte C, Cid J, Albaiges J (1990) Determination of organophosphorus compounds in Mediterranean coastal waters and biota samples using gas-chromatography with nitrogen-phosphorus and chemical ionization mass-spectrometric detection. Int J Environ Anal Chem 38(2) 199-209... 

Liquid chromatography with electrospray ionization mass spectrometric detection of phenolic compounds from Olea europaea. J Chromatogr A 1999 OE065... 

S Lacorte, G Jeanty, JL Marty, D Barcelo. Identification of fenthion and temephos and their transformation products in water by high-performace liquid chromatography with diode array detection and atmospheric pressure chemical ionization mass spectrometric detection. J Chromatogr A 777 99-114, 1997. 

Heath, T. G. Giordani, A. B. 1993. Reversed-phase capillary high-performance liquid chromatography with on-line UV, fluorescence and electrospray ionization mass spectrometric detection in the analysis of peptides and proteins. J. Chromatogr., 638,9-19. 

For several years LC detectors were limited to refractive index and ultraviolet absorption systems. Recently introduced systems include the electrochemical detector and a moving belt interface allowing for chemical ionization-mass spectrometric detection. Both of these techniques provide a degree of selectivity not previously available. 

M. Kotrebai, J. F. Tyson, E. Block, P. C. Uden, HPLC of selenium compounds utilizing perBuorinated carboxylic acid ion-pairing agents and inductively coupled plasma and electrospray ionization mass spectrometric detection, J. Chromatogr. A, 866 (2000), 51D63. 

Lacker, T. SSohschein, S. Albert, K. 1999. Separation and identification of various carotenoids by C30 reversed-phase high-performance liquid chromatography coupled to UV and atmospheric pressure chemical ionization mass spectrometric detection. J. Chromatogr. A 854 37-44. 

High-performance liquid chromatography equipped with diode array (HPEC-DAD) and electrospray ionization mass spectrometric detection (ESI-MS(n)) has been used to identify anthocyanins in muscadine grapes (Sandhu et ah, 2010). Six different anthocyanin 3,5-diglucosides were identified in muscadine grape skins (Sandhu et al., 2010). 

Chemical ionization mass spectrometric detection has been explored for the detection of methyl hydroperoxides However, fluorometry has dominated the current detection schemes for the organic peroxides. Typically, a nonfluorescent substrate is oxidized by the peroxide to generate a fluorescent product. These methods are sufficiently sensitive for accurate measurement of the peroxides in the low ppt by volume. For example, the peroxidase-catalyzed dimerization of p-hydroxyphenylacetic acid (POPHA) occurs in the presence of a peroxy group at elevated pH. The formation of the fluorescent dimer, detected by excitation at 310 nm and emission at 405 nm, is proportional to the concentration of the peroxide. The most common peroxidase catalyst used for this reaction is horseradish peroxidase (HRP). Cost and stability issues with the use of HRP led to the use of other catalysts, such as metalloporphyrins or phthalocyanine complexes. Another fluorescent reaction scheme involves the oxidation of the nonfluorescent thiamine (vitamin Bi) to the fluorescent thiochrome by the peroxide group. This reaction is catalyzed by bovine hematin. This reaction is 25-fold more sensitive for H2O2 than for the organic peroxides. 

Messer, B. M., Stiestra, D. E., Cappa, C. D., Scholtens, K. W., and Elrod, M. J., Computational and experimental studies of chemical ionization mass spectrometric detection techniques for atmospherically relevant peroxides, Int. J. Mass Spectrom., 197, 219-235, 2000. 

Dost, K., Jones, D. C., Auerbach, R., and Davidson, G., Determination of pesticides in soil samples by supercritical fluid chromatography-atmospheric pressure chemical ionization mass spectrometric detection. Analyst, 125, 1751-1755, 2000. 

M. Himmelsbach, W. Buchberger and C.W. Klampfl, Determination of antidepressants in surface and waste water samples by capillary electrophoresis with electrospray ionization mass spectrometric detection after preconcentration using off-hne sohd-phase extraction. Electrophoresis, 27,1220-1226, 2006. 

Taylor MR, Teale P (1997) Gradient capillary electrochromatography of drug mixtures with UV and electrospray ionization mass spectrometric detection. J Chromatogr A 768 89-95... 

Cappiello s research group applied micro-HPLC to the screening of water samples for pesticide contamination. With electron ionization mass spectrometric detection and the use of two microcolumns packed with a Cig silica-based stationary phase, they performed the preconcentration of water samples and successfully detected trace levels of pollutants in similar samples. They also showed that ion-interaction micro-HPLC on a Cig stationary phase with hexylamine as the ion-pair reagent and coupling to particle beam mass spectrometry could be successfully used for the analysis of herbicides ranging from acidic species such as... 

Ayano, E. et al.. Determination and quantitation of sulfonylurea and urea herbicides in water samples using liquid chromatography with electrospray ionization mass spectrometric detection, Anal. Chim. Acta, 507, 215,2004. 

Dugo P, Kumm T, Chiofalo B, Cotroneo A, Mondello L. Separation of triacylglycerols in a complex lipidic matrix by using comprehensive two-dimensional liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometric detection. J Sep Sci 2006 29 1146—54. 

Sherman CL, Brodbelt JS, Marchand AP, Poola B (2005) Electrospray ionization mass spectrometric detection of self-assembly of a crown ether complex directed by a-stacldng interactions. J Am Soc Mass Spectrom 16(7) 1162-1171. doi 10.1016/j.jasms.2005.03.014 Shivanyuk A, Rafai Far A, Rebek J Jr (2002) Rigid tetra-nitroresorcinarenes. Oig Lett 4(9) 1555-1558. doi 10.1021/ol025725h... 

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