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Investigation of Proteome Expression and Function

Protein expression and function under various physiological conditions can be investigated by employing 2DE techniques. Quantitative regulation of proteomics allows us to monitor quantitative changes in protein expression within a cell or tissue under different circumstances, particularly in a disease state. [Pg.87]

Two features of expression profiling make it the most productive approach to study biological systems for the immediate future. First, the present efficiency with which investigators can obtain global and quantitative information with DNA arrays exceeds that of proteomic techniques. Second, RNA expression profiles provide an extremely precise and reproducible signature of the state of the cell that probably reflects albeit indirectly, the functional state of all proteins (Young, 2000, p. 13)-... [Pg.344]

Cell map proteomics reveals the static proteome of a whole organism, tissue, cell or organelle, while expression proteomics investigates changes in a proteome to cellular cues (Godovac-Zimmermann and Brown, 2001). Functional and structural proteomics refers to the investigation of individual proteins such as interactions with ligands. [Pg.328]

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Expression proteomics

Functional investigations

Proteome expression/function

Proteome expression/function investigation

Proteomics expression/function

Proteomics functional

Proteomics functions

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