Proteome expression/function

Finally, it is a pleasure to acknowledge the very considerable behind the scenes help from all those who helped make the conference a success. We would like to thank Anne Tuson and Marg Hedges, as well as all the members of the Mammalian Behaviour and Evolution Group and the Proteomics and Functional Genomics Group at the University of Liverpool. We would also like to express our thanks to the University of Chester Conference Team for their support and efforts at the venue. 

General consensus has sub-divided proteomics into three main areas, Expression Proteomics, Functional Proteomics, and Structural Proteomics. Expression Proteomics (sometimes called differential-expression proteomics) involves the analysis of differential protein expression by protein... 

Scientists are now trying to determine the primary sequence and functional role of every protein expressed in a living cell, known as its proteome. 

Proteomics, the measurement of the global changes in proteins produced as a result of gene expression, bridges the gap between genome sequence and cellular behaviour and takes into account the post-translational modifications that often result in the functional effect. It has the potential to determine the role of protein-protein complexes in the complex signalling cascades that... 

Two features of expression profiling make it the most productive approach to study biological systems for the immediate future. First, the present efficiency with which investigators can obtain global and quantitative information with DNA arrays exceeds that of proteomic techniques. Second, RNA expression profiles provide an extremely precise and reproducible signature of the state of the cell that probably reflects albeit indirectly, the functional state of all proteins (Young, 2000, p. 13)-... 

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