Introduction growth hormone

With the introduction of genetic engineering in the 1970s it became possible to produce pharmaceutical proteins like human insulin and human growth hormone (hGH) by microbial fermentations, leading to the development of what is often referred to as the biotech industry. 

The introduction of rDNA human growth hormone (hGH) (70), previously isolated from cadaver pituitaries, greatly improved the long-term treatment of children who have growth failure caused by a lack of adequate endogenous hGH. The major, circulating form of human pituitary hGH is a globular protein of 191 amino acids in... 

Marian M. Growth hormones. In Crommelin, DJA, Sindelar RD, eds. Pharmaceutical Biotechnology An Introduction for Pharmacists and Pharmaceutical Scientists. Amsterdam Harwood Academic Publishers, 1997 241-253. 

In the former the relative risk of tumor recurrence after introduction of growth hormone replacement compared with pre-treatment was 1.34 (95% CI=0.23, 7.8). In the latter the relative risk of tumor recurrence in patients treated with growth hormone was 1.36 (95% Cl=0.28, 5.5). 

Hormone-sensitive tumors may regress, and frequently stop growth upon introduction of certain hormones. The main hormone-sensitive forms of cancer are breast and prostate carcinoma, lymphoma, and a few other forms of carcinomas. 

With a number of juvenile hormone analogues it could be shown that the concept of insect control by interaction with their hormone system is valid (28, 29). In view of the slow progress with compounds affecting the hormone system of ecdysteroids (30) the introduction of brassinosteroids may give some new impetus to the search for ecdysteroid-based insect growth regulators. 

---