Intraventricular lesions

Administration of HA and its effect on sleep-wakefulness Local application of HA (5, 30 and 60 pg) in the TMN region of cats increased the latency to sleep, increased arousal, and reduced NREM sleep in a site-specific, dose-dependent manner. The highest dose produced the maximal effect, which lasted for 6 h. The HA-induced arousal was completely blocked when the cats were pretreated intraperitoneally with the Hi receptor antagonist mepyramine (Lin et at, 1986, 1988). In rats, intraventricular administration of HA blocked the increase in delta and theta activity (0-6 Hz) in the EEG induced by repeated low-frequency stimulation of the midbrain reticular formation. This effect was blocked if specific thalamic nuclei were lesioned (Tasaka et at, 1993) or by simultaneous administration of an Hi receptor antagonist, but not by an H2 receptor antagonist (Tasaka et at, 1989). Application of HA... 

Muir JL, Dunnett SB, Robbins TW, et al Attentional functions of the forebrain cholinergic systems effects of intraventricular hemichohnium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp Brain Res 89 611-622, 1992 Mukherjee S Mechanisms of the antimanic effect of electroconvulsive therapy. Convulsive Therapy 5 227-243, 1989... 

Passini, M. A. et al. (2003). Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-deficient mice. J. Virol. 77(12), 7034-7040. 

INTRAVENTRICULAR/BILATERAL NIGROSTRIATAL 6-OHDA LESION SYNDROME... 

Zigmond MJ, Strieker EM (1973) Recovery of feeding and drinking by rats after intraventricular 6-hydroxydopamine or lateral hypothalamic lesions. Science 752 717-720. 

ECG abnormalities in children who ingested castor beans have been noted by Kaszas and Papp (1960). These include QT interval lengthening, repolarization changes, and intraventricular conduction disturbances. Crompton (1980) later reported on experiments on pigs that experienced hemorrhagic lesions and an abnormal ECG due to ricin. At the present time, no antidotes or effective therapy are available to counteract the effects of ricin. 

Chadi, G., Moller, A., Rosen, L., Janson, A. M., Agnati, L. A., Goldstein, M., Ogren, S. O., Pettersson, R. F., and Fuxe, K., Protective actions of human fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion, lixp. Brain Res., 97, 145, 1993. 

High concentration of extracellular potassium (50 mM), which results in cellular depolarization, decreases NGF production by 30% in explanted rat iris (Hellweg et al., 1988). In contrast, elevated potassium levels increase the concentration of rjjRNANGF jjj cultured hippocampal neurons (2 fra et al., 1990). Depolarization produced by electrolytic lesions or systemic intraventricular administration of glutamate receptor agonists produces a rapid rise in mRNA p in vivo (Gall and Isackson, 1989 Zafra et al., 1990 Gall et al., 1991). 

Hefti, F., David, A. and Hartikka, J. (1984) Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with parietal septo-hippocampal lesions. Brain Res. 293 311-317. 

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