Intestinal peptide transporter PepTl

Wenzel, U., Gebert, I., Weintraut, H., Weber, W.-M., Clauss, W., Daniel, H., Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepTl and in human intestinal Caco-2 cells, J. Pharmacol. Exp. Ther. 1996, 277, 831-839. 

Doring, F., S. Theis, and H. Daniel. Expression and functional characterization of the mammalian intestinal peptide transporter PepTl in the methylotropic yeast Pichia pastoris. Biochem. Biophys. Res. Commun. 1997, 232, 656-662. 

Meredith, D., Temple, C.S., Guha, N., Sword, C.J., Boyd, C.A., Collier, I.D., Morgan, K.M. and Bailey, P.D. (2000) Modified amino acids and peptides as substrates for the intestinal peptide transporter PepTl. European Journal of Biochemistry, 267 (12), 3723-3728. 

Shiraga, T., Miyamoto, K., Tanaka, H., Yamamoto, H., Taketani, Y. et al, Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepTl, Gastroenterology 1999, 3 36, 354-362. 

Brodin, B., et al. Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepTl. Pharmacol. Toxicol. 2002, 90, 285-296. 

Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepTl, Gastroenterology 1999, 116, 354-362. 

Wang, H., Ganapathy, V., Valad-dovir a substrate for the intestinal and renal peptide transporters PepTl and PepT2, Biochem. Biophys. Res. Commun. 1998, 246, 470—475. 

After the break down of proteins by proteolytic enzymes, the pancreas, and brush border peptidases, the di- and trip-eptides are absorbed through the epithelial cell membrane. Many studies have shown that intact di- and tripeptides are absorbed across the epithelial cell membrane by active transport via specific carrier systems. The absorption process is mediated by the hydrogen-coupled peptide transporter (PEPTl) located in the intestinal apical cell membrane. Because there are 20 amino acids, there may be 400... 

Ziegler, T.R., Fernandez-Estivariz, C., Gu, L.H., Bazargan, N., Umeakunne, K., Wallace, T.M., Diaz, E.E., Rosado, K.E., Pascal, R.R., Galloway, J.R. et al. (2002) Distribution of the H + /peptide transporter PepTl in human intestine up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. The American Journal of Clinical Nutrition, 75 (5), 922-930. 

Res. Commun., 246, 470 (1998). Valacyclovir A Substrate for the Intestinal and Renal Peptide Transporters PEPTl and PEPT2. 

Ihara, T., et al. Regulation of PepTl peptide transporter expression in the rat small intestine under malnour-... 

Exceptions from Lipinski s rule, i.e., molecules of PSA values > 140 A2 are found to be actively absorbed by carrier-mediated transport systems (Wessel et al. 1998), as shown in Fig. 3. IB. As further detailed in Fig. 3.2, the intestinal epithelium expresses a number of such transport systems for amino acids, organic anions and cations, nucleosides, and hexoses. Among these systems are the apical sodium-dependent bile acid transporter (ASBT Annaba et al. 2007), the monocarboxylate transporter (MCT Halestrap and Price 1999), the sodium-D-glucose co-transporter (SFGT1 Kipp et al. 2003), and the nucleotide transporter SPNT1 (Balimane and Sinko 1999). In addition, the expression of a specialized transporter system for small peptides has been found in the intestinal epithelium with the di/tripeptide transporter, PepTl (Tsuji 2002), after previous functional studies by Hu et al. (1989), and the cloning of PepTl... 

Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP et al. 5 -Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPTl peptide transporter. Pharm Res 1998 15 1154-9. 

Amasheh, S., Wenzel, U., Boll, M., Dorn, D., Weber, W., Clauss, W. and Daniel, H. (1997) Transport of charged dipeptides by the intestinal H + /peptide symporter PepTl expressed in Xenopus laevis oocytes. The Journal of Membrane Biology, 155 (3), 247-256. 

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