Intestinal intraepithelial lymphocytes lELs

To clarify the mechanisms of antitumor actions of various chitosans, we examined the cytotoxic activity against YAC-1 (NK cell-sensitive target ceils) or sarcoma 180 cells by intestinal intraepithelial lymphocytes (lELs) or splenic lymphocytes treated various chitosans. Treatment of lELs with oligochitosan (10 to 1000 jlg/mL), chitosan-21 (10 to 1000 jXg/mL), or chitosan-46 (10 to 1000 jXg/mL) enhanced their c>i otoxic activity against YAC-1 cells compared with that of untreated lELs Fig. (12) . 

MCMILLAN DN, SECOMBES CJ (1997), Isolation of rainbow trout (Oncorhynchus mykiss) intestinal intraepithelial lymphocytes (lEL) and measurement of their cytotoxic activity , Eish Shellfish Immunol, 7, 527-41. 

Lamina propria lymphocytes (LPLs) and intraepithelial lymphocytes (lELs), along with Peyer s patches (PPs) and other intestinal lymphoid nodules, combine to form one of the largest and most unappreciated, lymphoid cell populations in the body (Cerf-Bensusan and Guy-Grand, 1991). Significant alterations to these populations, as well as the PPs, can open the door to potentially lethal bacterial and protozoal overgrowth followed by systemic invasion. 

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