International Center for Toxicology and

Dr. Ronald Gots, International Center for Toxicology and Medicine... 

Offers direct access to virtually all of the world s scientific and data bases for toxicology and related information. Covers chemicals, pesticides, food additives, industrial chemicals, heavy metals, environmental pollutants, and pharmaceuticals. The Center is online to more than 400 computerized databases, including DIALOG, MEDLARS, STN International, ITIS, and DROLS. It performs searches for outside users for a fee. 

An ISO standard, it should be noted, is a document that undergoes periodic review and is subject to revision. Recently, the FDA, more specifically the Center for Devices and Radiological Health (CDRH), has been considering the use of international consensus standards for the toxicological evaluation of medical devices. 

Japan s Ministry of International Trade has published several books with detailed information on biodegradation tests of several hundred chemicals. This information has now also been made available by the Japan Chemical Industry Ecology-Toxicology and Information Center (JETOC) see Chapter 14 for more details on the MITI biodegradation database. The JETOC also published a compendium of mutagenicity test data of several hundred chemicals. The books can be purchased from JETOC and partial data can be found at various websites, such as members.jcom.home.ne.jp/mo-ishidate/. 

A peer review panel was assembled for 1,1-dichloroethane. The panel consisted of the following members Dr. Benjamin Van Duuren, Institute of Environmental Medicine, New York University Medical Center Dr. James Bruckner, Department of Toxicology and Pharmacology, University of Georgia Dr. Theodore Mill, director. Physical Organic Chemistry Department, SRI International Dr. Nancy Tooney, Associate Professor, Department of Chemistry, Polytechnic University, Brooklyn, New York and Ms. Linda Massey, Private Toxicology Consultant, Santa Clara, California. These experts collectively have knowledge of 1,1-dichloroethane s physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(i) (13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. 

This document was written by Dr. Dennis M. Opresko, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN. Internal peer review was provided by Dr. Robert Young, Dr. Annetta Watson, and Mr Robert Ross. External review of the toxicity data was provided by Dr. Thomas J. Bucci, Integrated Services, White HaU, AR and Dr. I.K Ho of the U. of Mississippi Medical Center, Jackson MS. External review of the derivation of the RfDs was provided by Drs. Michael Dourson and Susan Velazquez of Toxicology Excellence for Risk Assessment, Cincinnati, OH, and Dr. William Hartley of Tulane Medical Center, New Orleans LA. Additional reviews were provided by Mr. Joe King, Dr. Jack Heller, Ms. Veronique Hauschild, Ms. Bonnie Gaborek, Mr. Maurice Weeks, Maj. Robert Gum, and Mr Kenneth Williams of the U.S Army. 

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