Interleukin 2 gene

Kaempfer, R. et al., Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression, J Clin. Oncol., 14, 1778, 1996. 

Ness, T.L. et al. Isolation and expression of the interleukin-2 gene from the killer whale, Orcinus orca, Mar. Mamm. Sci, 14, 531, 2000. 

Junbo, H., Q. Li, W. Zaide, and H. Yunde, Receptor-mediated interleukin-2 gene transfer into human hepatoma cells. Int J Mol Med, 1999. 3(6) 601-8. 

Li D, Jiang W, Bishop S, Ralston R, et al. 1999. Combination surgery and nonviral Interleukin-2 gene therapy for head and neck cancer. Clin Cancer Res. 5 1551-1556. 

Li, B., Sehajpal, P. K., Khanna, A., Vlassara, H., Cerami, A. et al. (1991). Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells Demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction./. Exp. Med. 174, 1259-1262. 

Wang, A., Lu, S-D., and Mark, D.F. (1984). Site-specific mutagenesis of the human interleukin-2 gene structure-function analysis of the cysteine residues. Science 224,1431 1433. 

Both drugs inhibit interleukin-2 gene transcription and the transition of T lymphocytes from the GO to G1 phase of the cell cycle. They bind to cytoplasmic immunophilins, cyclophilin for CSA and FK-binding protein (FKBP12) for TAC. The immunosuppressive... 

Parker, S. E., Khatibi, S., Margalith, M., Anderson, D., Yankauckas, M Gromkowski, S. H., Latimer, T Lew, D., Marquet M Manthorpe M., Hobart, P., Hersh, E., Stopeck, A. T and Norman, J. (1996) Plasmid DNA gene therapy studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo. Cancer Gene Ther. 3(3), 175-185. 

Rothenberg, E. V., Ward, S. B. (1996) A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93, 9358-9365. 

Alroy, I., Towers, T.L. and Freedman, L.P. (1995) Transcriptional repression of the interleukin-2 gene by vitamin D3 direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Molecular and Cellular Biology, 15, 5789-5799. 

B. Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes. / Autoimmunol. 2, Suppl., 55-65 (1989). 

Kamps, M. P., Corcoran, L., LeBowitz, J. H., and Baltimore, D. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. Mol. Cell. Biol. 10, 5464-5472 (1990). 

VI. Vacca, A., Martinotti, S., Screpanti, 1., Maroder, M., Felli, M. P., Farina, A. R., Gismondi, A., Santoni, A., Frati, L., and Gulino, A. Transcriptional regulation of the interleukin-2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5 -flanking sequences. J. Biol. Chem. 265, 8075-8080 (1990). 

Yea, S.S., Yang, K.H., Kaminski, N.E (2000) Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells. J. Pharmacol. Exp. Ther. 292, 597-605. 

DOTMA/Cholesterol [Ratio 1 0.5(-/+)] Liposomes interleukin-2 gene Head and neck cancer cells II NCT00006033... 

Yang, Y, Chen, J., Li, H. et al. 2007. Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine. Comp. Immunol. Microbiol. Irfiect. Dis. 30 19-32. 

Inhibition of calcineurin results in T cells that no longer respond to antigen presentation thus, they no longer can transcribe the interleukin-2 gene and cannot undergo interleukin-2-dependem proliferation. In contrast, inhibition of FRAP acts at a later step... 

Pournaghi-Azar, M.H., Hejazi, M.S. and Alipour, E. (2006) Developing an electrochemical deoxyribonucleic acid (DNA) biosensor on the basis of human interleukine-2 gene using an electroactive label. AnaZ. Chim. Acta, 570 (2), 144-150. 

Muller-CJuemheim J, Saltini C, Sondermeyer P, et al. Compartmentalized activation of the interleukin-2 gene by lung T-lymphocytes in active pulmonary sarcoidosis. J Immunol 1986 137 3475-3483. 

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