Interactions Weiss domains

The precise chemical interactions between an adhesin and its receptor are also important. For example, direct- and water-mediated hydrogen bonds are the most important interactions within the carbohydrate-recognition domain in carbohydrate-binding adhesins on the host cell surface (Weis and Drickamer, 1996). Nonpolar van der Waals interactions and hydrophobic "stacking of the receptor oligosaccharide rings with aromatic amino acid side chains of the bacterial adhesin protein also contribute to oligosaccharide-protein interactions. X-ray structural... 

Hill, J. M., Morisawa, G., Kim, T., Huang, T., Wei, Y., and Werner, M. H. (2004). Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas. / Biol Chem. 279, 1474-1481. 

The substrates N-j3-Gal and IBB-NPL are fusions proteins consisting of the domain of importin a that interacts directly with importin linked to -galactosidase or the core domain of Xenopus nucleoplasmin, respectively (Weis et al., 1996b Gorlich et ai, 1996a, 1996b). 

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