Intramolecular interaction effects, carbonyl compounds

General discussion of intra- and intermolecular interactions 3 van der Waals interactions 3 Coulombic interactions 5 Medium effects on conformational equilibria 5 Quantum mechanical interpretations of intramolecular interactions 7 Methods of study 8 Introduction 8 Nmr and esr spectroscopy 8 Microwave spectroscopy (MW) 12 Gas-phase electron diffraction (ED) 12 X-ray crystallographic methods 13 Circular-dichroism spectroscopy and optical rotation 14 Infrared and Raman spectroscopy 18 Supersonic molecular jet technique 20 Ultrasonic relaxation 22 Dipole moments and Kerr constants 22 Molecular mechanic calculations 23 Quantum mechanical calculations 25 Conformations with respect to rotation about sp —sp bonds 27 Carbon-carbon and carbon-silicon bonds 28 Carbon-nitrogen and carbon-phosphorus bonds 42 Carbon-oxygen and carbon-sulphur bonds 48 Conformations with respect to rotation about sp —sp bonds Alkenes and carbonyl derivatives 53 Aromatic and heteroaromatic compounds 60 Amides, thioamides and analogues 75 Conclusions 83 References 84... 

Similarly, in the studies of these compounds, people found that the intramolecular hydrogen-bonding interaction between C-6 hydroxyl and C-15 carbonyl in alpha methylene cyclopentanone also played an important role in antitumor activity. Take eriocalyxin B for example, it has inhibitory effects on six kinds of human cancer cells, i.e. K562, HL-60, A549, MKN-28, HCT and CA, where significant cell apoptosis can be observed. In 2007, Chinese academicians Zhu... 

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