Interaction compounds

Peptoid hbraries have also yielded compounds active in the disruption of RNA-protein interactions. Compounds not derived from library syntheses are discussed in Section 1.4.1. A peptoid 9-mer with a number of cationic groups was discovered (Fig. 1.4) after several rounds of mixture deconvolution, that was able to block the interaction of HIV-1 Tat protein with TAR RNA at nanomolar concentra-... 

Membrane-interactive compounds are lipophilic molecules which have high affinity for lipid membranes and consequently possess long membrane residence times. Examples include the lipophilic neutral molecules (cholesterol, lecithin, pesticides, oleyl alcohol, tocopherols, etc.) and large organic cations (chlorproma-... 

In conclusion, Eqs. (140) and (141) are applicable to quantify not only the transmonolayer kinetics of highly membrane interactive permeants, but also the kinetics of less membrane interactive compounds. Notably, the examples emphasize the importance of simultaneously measuring the disappearance of a compound from the donor solution and its appearance in the receiver and demonstrate how interactions with proteins on either side of the cellular barrier influence permeability. 

Table 16.1 QSPR and pharmacophore models for P-gp interacting compounds. 

Sun D, Thompson B, Gathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH (1997) Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem 40 2113-2116... 

A special case is when the electrochem-ically active components are attached to the metal or carbon (electrode) surface in the form of mono- or multilayers, for example, oxides, hydroxides, insoluble salts, metalloorganic compounds, transition-metal hexacyanides, clays, zeolites containing polyoxianions or cations, intercalative systems. The submonolayers of adatoms formed by underpotential deposition are neglected, since in this case, the peak potentials are determined by the substrate-adatom interactions (compound formation). From the ideal surface cyclic voltammetric responses, E° can also be calculated as... 

Key Words Ras Raf yeast two-hybrid system protein interaction compound library cell-based screening. 

Rollag JG, Nachi R, Schlesiger L, et al. The resolution of ion suppression caused by drug-interaction compounds. (2001) ASMS Conference Proceedings. 

A second strategy was recently proposed that both increases the sensitivity and allows in certain cases more direct information about the binding site of the interacting compounds [115], It is based on correlation experiments... 

An x-ray crystallographic analysis of bcnzo[J,2,3- / 4,5,6-cV ]bis(thieno)[2,3-c]thiophene (61) demonstrated that the molecule is planar and symmetrical but has strained bond angles. The crystal structure comprises herring-bone type column stacking with intercolumnar heteroatom interactions. Compound (61) showed the same oxidation potential as perilene and, like perilene, formed an iodine complex with the relatively high electroconductivity of 0.11 S cm-1 <93BCJ2033>. 

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