Insulin Fluoxetine

Breum L, Bjerre U, Bak JF, Jacobsen S, Astrup A (1995) Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance influence on muscle glycogen synthase and insulin receptor kinase activity. Metabolism 44 1570-1576... 

ASA = aspirin NSAIDs = non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen, and diclofenac CNS stimulants include drugs such as pseudoephedrine, dextroamphetamine, theophylline, and caffeine MAO = monoamine oxidase CNS depressants include drugs such as benzodiazepines, barbiturates, and ethanol SSRIs = selective serotonin reuptake inhibitors, such as fluoxetine, sertraline, and paroxetine. Antidiabetic agents include drugs such as insulin, glipizide, glyburide, and metformin. 

Clinically important, potentially hazardous interactions with caffeine, carbamazepine, cocoa, fluoxetine, guarana, insulin glulisine, risperidone, ritonavir, selenium, uracil/tegafur... 

Clinically important, potentially hazardous interactions with aceclofenac, acetazolamide, acitretin, bendroflumethiazide, benzthiazide, chlorothiazide, chlorthalidone, cocoa, desvenlafaxine, etoricoxib, fluoxetine, guarana, haloperidol, hydrochlorothiazide, hydroflumethiazide, indapamide, insulin detemir, insulin glulisine, meperidine, mesoridazine, methotrexate, methyclothiazide, metolazone, olmesartan, pegfilgrastim, phenylbutazone, polythiazide, quinethazone, rocuronium, rofecoxib, sibutramine, sulpiride, tenoxicam, thiazides, trichlormethiazide, valdecoxib, xipamide, zofenopril, zuclopenthixol... 

There are anecdotal data indicating enhanced hypoglycemia capacity when fluoxetine is added to hypoglycemic agents or given to insulin-dependent patients. 

There would seem to be little reason for avoiding concurrent use of fluoxetine, fluvoxamine or sertraline with sulphonylureas, but until more is known it would seem prudent to monitor diabetic control. The manufacturers of fluoxetine, paroxetine and sertraline warn that dosages of insulin or oral antidiabetics may need adjustment during concurrent use. ... 

Daubresse J-C, Kolanowski J, Krzentowski G, Kutnowski M, Scheen A, Van Gaal L. Usefulness of fluoxetine in obese non-insulin-dependent diabetics a multicenter study. ObesRes... 

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