Insufficient data

If there is insufficient data to describe a continuous probability distribution for a variable (as with the area of a field in an earlier example), we may be able to make a subjective estimate of high, medium and low values. If those are chosen using the p85, p50, pi 5 cumulative probabilities described in Section 6.2.2, then the implication is that the three values are equally likely, and therefore each has a probability of occurrence of 1/3. Note that the low and high values are not the minimum and maximum values. 

Unfortunately, insufficient data make it impossible to know whether the activity coefficients of all aromatic compounds vary slightly, or whether certain compounds, or groups of compounds, show unusual behaviour. However, it seems that slight variations in relative rates might arise from these differences, and that comparisons of reactivity are less sound in relatively concentrated solutions. 

Because of the high vapor pressure of the simple quinones and their penetrating odor, adequate ventilation must be provided in areas where these quinones are handled or stored. Quinone vapor can harm the eyes, and a limit of 0.1 ppm of 1,4-benzoquinone in air has been recommended. Quinone in either sohd or solution form can cause severe local damage to the skin and mucous membranes. Swallowing benzoquinones may be fatal the LD q in rat is 130 mg/kg orally and 0.25 mg/kg intravenously. There is insufficient data concerning quinones and cancer. The higher quinones are less of a problem because of their decreased volatihty (118—120). 

The solubihty coefficients are more difficult to predict. Although advances are being made, the best method is probably to use a few known solubility coefficients in the polymer to predict others with a simple plot of S vs ( poiy perm Y where and are the solubility parameters of the polymer and permeant respectively. When insufficient data are available, S at 25°C can be estimated with equation 19 where k = 1 and the resulting units of cal/cm are converted to kj /mol by dividing by the polymer density and multiplying by the molecular mass of the permeant and by 4.184 (16). 

Prolonged contact with certain chromium compounds may produce allergic reactions and dermatitis in some individuals (114). The initial response is usually caused by exposure to Cr(VI) compounds, but once the allergy is estabUshed, it is extended to the trivalent compounds (111,115). There is also limited evidence of possible chromium associated occupational asthma, but there is insufficient data to estimate a dose for assumed chromium-induced asthma. Reference 116 provides a summary and discussion of chromium hypersensitivity. 

In general, aza substitution (replacement of cyclic CH by N) has little effect on UV spectra (Table 23). Typically, aza analogs of pyrrole show A max at 217 nm or lower with log e ca. 3.5, whereas aza analogs of thiophene show Amax at 230-260 nm with log e ca. 3.7 (Table 23) insufficient data are available for aza analogs of furan to generalize but these compounds appear to have maxima below 220 nm. 

Proper assignment of tolerances is one of the least well-understood engineering tasks (Gerth, 1997). Assignment decisions are often based on insufficient data or incomplete models (Wu et al., 1988). The precise assignment of the component tolerances for this combined effect is multifarious and is dictated by a number of factors, including ... 

Insufficient data were available to confirm the exact source of the problem. So, a program to collect the additional data was conducted. 

Biological monitoring should be considered for this compound based on the review however, a specific BEI could not be determined due to insufficient data. 

This implies, for example, that measurements taken over a given period of time may give insufficient data to integrate workplace factors in the series of activities in the period under consideration in such a way as to permit assessment of the likely maximum risk to which the individual workers are exposed. 

Column temperature alarm Not a complete indication at this stage. It may be a spurious alarm Cross-examine related indicators Data collection Can operator acquire irrelevant or insufficient data Can operator fail to crosscheck for spurious indications Identification/lnterpretation Can operator fail to consider all possible system states and causes of problem Can operator fail to perform a correct evaluation Can operator fixate on the wrong cause Goal Selection Can operator fail to consider possible side-effects Can operator fail to consider alternative goals Can operator fixate on the wrong goal ... 

If, as is usually the case, there are insufficient data to allow the calculation of an empirical relationship between the SLIs and error probabilities, then a mathematical relationship has to be assumed. The usual form of the assumed relationship is log-linear, as shown below ... 

Recommend applying only for methane, propane, and solvent vapors due to insufficient data and for a static activation pressure of the relief device of Ps,ai =0.1 bar (see reference [54]). 

Unclassified refrigerants indicate either insufficient data to classify or no formal request for classification. ... 

As Barrer and Stuart4 have already demonstrated, insufficient data are available to give a quantitative analysis of the change of composition of a hydrate along the three-phase line ice-hydrate-... 

The LC50 refers to the wastewater concentration which results in 50 percent mortality under the test conditions (see text). It is an extrapolated value with varying confidence limits. In the work summarized here confidence limits were quite variable and often could not be calculated due to insufficient data points. Nevertheless the data satisfies the primary intent of the tests as a screening tool. 

Communication flow Acceptability outside the hierarchy versus adherence to hierarchy The extent to which people are conditioned to seek information, knowledge and views outside the organization Insufficient data currently available to accurately distinguish between countries... 

Force constants of have been calculated from the data in Table 2 using the general valence force field (GVFF) [148, 149] as well as the Urey-Bradley force field [80] (UBFF) although there is insufficient data to evaluate all the interaction constants since no isotopomers of Se have been measured by vibrational spectroscopy. The stretching and bond interaction force constants were reported as/r = 2.24 andf = 0.53 N cm, respectively [149]. However, because of the uncertainty regarding the Am mode of Se the published force constants [80, 148, 149] maybe unreliable. 

Dibutyltin Monooctyltin 2.6 1.0 Immunotoxicity Insufficient data to establish a TDI indications that MOT less immunotoxic than DOT 1000... 

There are insufficient data to conduct a probabilistic estimate of no-effect concentrations. For each of the organotins, the following outlines the reasoning for selection of studies and application of uncertainty factors ... 

Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken. Butinorate, Davainex and Tinostat are trade names. Card has been partially updated in 2006 see section Ingestion First Aid... 

At present, insufficient data are available, but the Tieszen and Fagre (1993) data set does give values for Bprothn and Bupid as well as Bcolla. together with Dcho and Dup and Fcho and Fup. It should therefore be possible to express BpRo and Bup in terms of the three main food components. Explicitly,... 

There are insufficient data to determine potential daily inhalation and dermal exposure levels. However, based on the information presented in Seetions 6.3 and 6.4, exposure levels for the general population are probably very low by these routes. Inhalation exposure is not important for the general population, with the possible exception of those individuals living near areas where methyl parathion is frequently sprayed. Since methyl parathion is readily adsorbed through the skin, dermal eontact may be the most relevant exposure pathway. Dermal eontaet is most likely to oeeur in people who are occupationally exposed. 

In rats, exposed males and females appear to have different sensitivities to the lethal effects of endosulfan exposure. Summary data submitted by Hoechst (1990) showed that female LDjg values ranged between 10 and 23 mg/kg, whereas male LDjo values ranged between 40 and 125 mg/kg. Thus, female rats appear to be 4-5 times more sensitive to the lethal effects of technical-grade endosulfan than male rats. This difference may be related to differences in the toxicokinetics of endosulfan in male and female rats (see also Section 2.3). Insufficient data were available to determine whether differences in sensitivity to lethal effects exist between males and females of species other than the rat. 

Figure 2. Relative toxicity (LD50 and LD qq) estimates for actiniid sea anemone toxins upon crabs (Carcimis maenas) and mice. Values for Anemonia sulcata (As) and Anthopleura xanthogrammica (Ax) toxins are from ref. 24 data for Condylactis gigantea and Phyl-lactis flosculifera toxins are unpublished (Kem). The arrows indicate that the real mouse LD q values for Cg II and Pf II must exceed the values indicated in the Ogure. Although insufficient data are presently available to quantitatively define a relationship between mammalian and crustacean toxicity, it seems that there is usually an inverse relationship, which may be approximately defined by the stipple zone.

Utility. Insufficient data Is available on the measurement of 1,25(0H)2D3 for evaluation of Its utility In clinical medicine. A major breakthrough In methodology will be needed before routine application will be possible. This could come with the development of a battery of radioimmunoassays for the measurement of all of the vitamin D metabolites. So far, however, the development of antibodies to vitamin D and Its metabolites has been limited by apparently Irreversable changes In the Important B ring of the sterol which occur during Its conjugation to Immunogenic proteins. 

Microorganisms surviving M. tuberculosis Bacterial spores HBV and prions as in Creutzfeldt-Jakob disease Bacterial spores Prions Extreme challenge of resistant bacterial spores Prions (insufficient data)... 

Based primarily on the study protocol of the 1995 NINDS rt-PA study.Many centers would also exclude patients with known documented endocarditis or aortic dissection, and those with CT hypoattenuation in more than one third of the middle cerebral artery territory. There are insufficient data to support the use of rt-PA for ischemic stroke in pregnancy or in the pediatric population (age <18 years). 

IV rt-PA has been safely given in patients with cervical arterial dissection There are four reports of IV rt-PA use in pregnancy, with one case complicated by intrauterine hematoma,rt-PA should be used in this setting only after careful assessment of the risks and benefits. There is insufficient data to determine the benefit of rt-PA in the pediatric population, with no randomized trials. 

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