Packaging injectable products

Injection-production wells, in soil and ground water treatment, 25 835 Injection stretch blow molding, of food packaging, 18 50-51 Injection wells, 18 613... 

SICOR (2005). Admcil . (Eluorouracil injection, USP) Package insert Y36-102-103. Available at newsicor.eom/products/pi/adrucil 6-2005 y36-102-103.pdf accessed 5/20/2007. 

Driscoll, D. F., Ling, P. R., and Bistrian, B. R. (2007), Physical stability of 20% lipid injectable emulsions via simulated syringe infusion effects of glass versus plastic product packaging, J. Parenteral Enteral Nutr., 31(2), 148-153. 

This chapter introduces the basic aspects of small-volume injectable products—their use, types and primary characteristics of dosage forms, formulation ingredients, and packaging systems. Additional information is available in a variety of reference texts and book chapters. Only conventional SVI... 

The uses of parenteral products for animals and the development process of these ate nearly identical to those products used for humans. The sterile dosage form types include solutions, suspensions, emulsions, and lyophilized powders. Any dosage form must be chemically, physically, and microbiologically stable, sterile, easy to inject, cause minimal pain and irritation upon injection, and packaged in appropriate vial sizes. Multiple-use vials are more common in animal health to treat herds/flocks). 

Interestingly, the product package insert for Choletec (kit for the preparation of technetium Tc 99m mebrofenin injection) (Choletec , 2000), which is an analogue of Hepatolite (1999) (kit for the preparation of technetium Tc 99m disofenin injection), records no cautionary statement regarding light sensitivity in the USP 27-NF 22 or in the package insert for technetium Tc 99m mebrofenin injection (Choletec , 2000). 

The choice of elastomer has the greatest effect on a formulation. The most common elastomers that can be used for closures for injectable products are given in Table 12.5. Of these elastomers, natural rubber, synthetic polyisoprene, butyl, chlorobutyl and bromobutyl rubber are typically used for the manufacture of rubber closures and stoppers used in the packaging and administration of parenterals. 

The excipient manufacturer must document the sanitizing of critical processing equipment such as centrifuges and dryers. Any manipulation of sterile excipients post-sterilization must be performed as a validated aseptic process. This is particularly important for those excipients which are not further sterilized prior to packaging into final containers. In some instances, the compendial monographs may specify that an excipient which does not meet parenteral grade standards be labelled as not suitable for use in the preparation of injectable products. Ethylene oxide is sometimes used for the sterilization of powders. The manufacture should validate that the ethylene oxide exposure does, in fact, produce a sterile product. 

Small Volume Parenteral A sterile injectable product intended for administration under or through the skin with a nominal fill volume of 100 mi or less. It may be packaged in glass or suitable plastic material. 

Example of an HACCP System. The HACCP system can be used to ensure production of a safe cooked, sHced turkey breast with gravy, which has been vacuum packaged in a flexible plastic pouch and subjected to a final heat treatment prior to distribution (37). Raw turkey breasts are trimmed, then injected with a solution containing sodium chloride and sodium phosphate. Next, the meat is placed into a tumbler. After tumbling, the meat is stuffed into a casing, placed onto racks, and moved into a cook tank, where it is cooked to an internal temperature of at least 71.1°C (160°F). After... 

Blow-molded products represent the biggest use of HDPE resins, at around 40%. Packaging appHcations account for by far the greatest share of this market. These include such products as botties (especially for milk, juice, and soap), housewares, toys, pails, dmms, and tanks. Expected aimual average growth rates for these appHcations are about 5—6%. Injection-molding products are the second largest appHcation, with approximately 20% of the HDPE market. These products include housewares, toys, food containers, pails, crates, and cases. 

Uses reported include motor housings for portable fans, food blender bases, tape storage housings, tough, clear toys, injection blow moulded products and thermoformed packages. 

Husky is a global supplier of injection molding systems to the plastics industry. Husky designs and manufactures injection molding machines—from 60 to 8000 tonnes, robots, hot runners for a variety of applications, molds for PET preforms, and complete preform molding systems. Customers use Husky s equipment to manufacture a wide range of products in the packaging, automotive and technical industries. The company serves customers in over 100 countries from more than 40 service and sales offices around the world. 

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