Inhibition of Free Radical Degradation in Medical Grade Hyaluronic Acid

Inhibition of Free Radical Degradation in Medical Grade Hyaluronic Acid 

Tamer Mahmoud Tamer, Katarma Valachova and Ladislav Soltes 

Historically, the first report about HA was written in 1880, when the French chemist Fortes observed a mucin in the vitreous body. 

The term hyaluronan was introduced in 1986 to conform to the international nomenclature of polysaccharides and it is attributed to Endre Balazs and co-workers [9], who coined it to encompass the different forms of the molecule, e.g, the acid form such as HA, and the salts, such as sodium hyaluronate, which forms at physiological pH. 

The hyaluronan polymer isolated from animals or bacteria is identical, and since bacterial hyaluronan is not immunogenic, it is an excellent source for medical grade hyaluronan. Extracting hyaluronan from microbial fermentation broth is a relatively simple process with high yields. An additional and important advantage of microbial hyaluronan production is that microbial cells can be physiologically and/or metabolically adapted to produce hyaluronan of high MW. 

---