Pregnancy influenza vaccine

Other preconception interventions with evidence of improving pregnancy outcomes include screening and immunization for rubella and varicella." Influenza vaccine is also recommended for women who will be in the second or third trimester during the influenza season." Pregnant women who contract influenza may have greater morbidity and mortahty owing to the risk of pneumonia."... 

Tamma PD, Ault KA, del Rio C, Steinhoff MC, Halsey NA, Omer SB. Safety of influenza vaccination during pregnancy. Am J Obstet Gynecol 2009 201 547-52. 

Previous studies assessing the safety of seasonal influenza vaccines in pregnancy did not find any safety concerns among... 

Although live attenuated influenza vaccines (seasonal or live HlNl vaccines) were not indicated during pregnancy, it is reassuring to know that inadvertent exposure to this vaccine in pregnant women did not result in unexpected reactions. 

No evidence exists of maternal or fetal risk when vaccine is given during pregnancy. Influenza vaccination is recommended for women who will be in the second and third trimesters of pregnancy during the influenza season because of increased risk for hospi-tahzation. 

Preventative vaccines are increasingly used during pregnancy, with the intention of protecting the newborn baby from infectious disease, such as influenza, via conferred immunity from the mother (1). To date, no causal relationships have been demonstrated for adverse effects on pregnancy with any approved vaccine. However, potential mechanisms have been suggested by which an induced immune response could interfere with prenatal development. A nonspecific disturbance of the resting balance between the innate and humoral activities of the immune system, for instance, could result in abortion (2). Otherwise, the induced antibodies may have the potential to disturb normal development due to a specific... 

Moro PL, Tepper NK, Grohskopf LA, VeUozzi C, Broder K. Safety of seasonal influenza and influenza A (HlNl) 2009 monovalent vaccines in pregnancy. Expert Rev Vaccines 2012 11(8) 911-21. 

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