Inflammatory bowel disease genetic factors

In summary, the true association between most dietary factors and risk of colon cancer is unclear. The protective effects of fiber, calcium, and a diet low in fat are not completely known at this time. Lifestyle factors such as NSAID use and hormone replacement use appear to decrease the risk of colorectal cancer, but questions remain about how to best use these agents. Obesity and alcohol use appear to increase risk of colon cancer, but their association is not well defined. Genetic and clinical risk factors such as inflammatory bowel disease are weU known risks for colon cancer. 

Susceptibility factors Genetic In 50 patients with systemic lupus erythematosus taking azathioprine, the erythrocytic concentrations of thioguanine nucleotides that were associated with clinical responses were lower than the target range established for inflammatory bowel disease [141 ]. 

Aside from their utility for the treatment of multiple skin manifestations, psoralens and UVA radiation could be used as a therapeutic alternative for several immune-mediated disorders as Crohn s disease and ulcerative colitis. Both are chronic inflammatory diseases of the gastrointestinal tract and are collectively known as inflammatory bowel disease. This disorder is produced by a dysfunction of the immtme system that leads to the accumulation of abtmdant lymphocytes and monocytes in the mucosa of the bowel, together with the secretion of cytokines and proinflammatory mediators. There are several genetic, environmental, and physiological factors that contribute to the pathogenesis of inflammatory bowel disease [151]. 

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