Inflammation Fibrinous

Plexiform vasculopathy Micro vascular inflammation Perivasular inflammation Fibrin exudation... 

These steioids aie capable of preventing or suppressing the development of the sweUing, redness, local heat, and tenderness which characterize inflammation. They inhibit not only the acute symptoms of the inflammatory process, such as edema, fibrin deposition, and capillary dilatation, but also the chronic manifestations. There is evidence that glucocorticoids induce the synthesis of a protein that inhibits phosphoHpase A 2 (60), diminishing the release of arachidonic acid from phosphoHpids (Fig. 2), thereby reducing chemotaxis and inflammation. 

Thrombus An aggregation of fibrin and platelets within a blood vessel. A thrombus often causes vessel obstruction, inflammation, and injury. 

Arterial thrombosis. The formation of an aggregate of blood factors (thrombus), primarily platelets and fibrin, with entrapment of cellular elements in the arteries. Arthritis. Inflammation of a joint. 

A 54-year-old woman and a 62-year-old man with catheter blockages both developed aseptic peritonitis (166). In both cases clots had earlier been removed by laparoscopy, which also showed diffuse thickening around the tip and in the peritoneal fat, with fluid accumulation or inflammation and whitish urticarialike plaques. The tissue was granulomatous, with histiocytes, fibrosis, and pseudo-amyloid material that could not be labeled by anti-insulin antibodies. The peritoneal fluid contained a lot of fibrin, monocytes, lymphocytes, and macrophages, but no bacteria or cancer cells. 

Fibrinogen is a fibrous protein that was first classified with keratin, myosin, and epidermin based on its 5.1 A repeat in wide-angle X-ray diffraction patterns (Bailey et al., 1943), which was later discovered to be associated with the Q-helical coiled-coil structure. It is a glycoprotein normally present in human blood plasma at a concentration of about 2.5 g/L and is essential for hemostasis, wound healing, inflammation, angiogenesis, and other biological functions. It is a soluble macromolecule, but forms a clot or insoluble gel on conversion to fibrin by the action of the... 

Inflammation is part of the first line response of the immune system to infection. Inflammation is characterized by two main components an exudative response and a cellular response. The exudative response involves the local recruitment of fluid (edema, swelling), containing proteins such as fibrin and immunoglobulins. The cellular response involves the release of cytokines from resident cells such as fibroblasts and the invasion of white blood cells into the inflamed tissue. Leukocytes take on an important role in inflammation by clearing the site from bacteria and cellular debris. In chronic inflammation an increased extravasation of neutrophils, monocytes, activated T cells, and macrophages to the inflamed site will persist. 

Fig.7 Blood compatibility of PEU surfaces modified by MPEO-derived SMAs. A Simplified cascade model for material-induced blood coagulation highlighting three clotting pathways plasma fibrin formation, platelet aggregation, and hemolysis-inflammation, respectively characterized by B-C...

Perihepatitis acuta gonorrhoica Of special relevance is a fibrinous inflammation of the subphrenic space without abscess formation, occurring as a sequel of gonorrhoeal adnexitis in women. It is also called the Fitz-Hugh-Curtis syndrome (A.H. Curtis, 1932 T. Fitz-Hugh, 1934),... 

Abscesses are the result of chronic inflammation and may occur without preceding generalized peritonitis. They may be located within one of the spaces of the peritoneal cavity or within one of the visceral organs and may range from a few milliliters to a liter or more in volume. These collections often have a fibrinous capsule and may take from a few weeks to years to form. 

MUCOPOLYSACCHARIDE POLY-SUL-PHATE This substance is absorbed percuta-neously and exerts a local antiinflammatory effect on superficial thrombophlebitis in the treatment of infusion thrombophlebitis it has been shown—using the 125—iodine fibrino gentest—that it produces a more rapid regression of the fibrin depot (the clot) in the area of inflammation. Also, the clinical symptoms were improved more rapidly. 

Thrombin (factor Ha) is the last enzyme protease involved in the coagulation cascade, and it converts fibrinogen to insoluble fibrin that forms the fibrin gel either in physiological conditions or in a pathological thrombus (28). Thrombin has also hormonelike properties, and it is involved in thrombosis and platelet activation. Therefore, thrombin plays a central role in a number of cardiovascular diseases (29), and it is thought to regulate many processes in inflammation and tissue repair at the vessel wall. 

M4. Makowski, G. S., and Ramsby, M. L., Interaction of amorphous calcium phosphate with fibrin in vitro causes decreased fibrinolysis and altered protease profiles Implications for atherosclerotic disease. Inflammation 25, 319-329 (2001). 

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