Infective endocarditis evaluation

Weinstein MP, Stratton CW, AcUery A, et al. Multicenter collaborative evaluation of a standardized serum bactericidal test as a prognostic indicator in infective endocarditis. Am J Med 1985 78 262-269. 

Torres-Tortosa M, de Cueto M, Vergara A, et al. Prospective evaluation of a two-week course of intravenous antibiotics in intravenous drag addicts with infective endocarditis. Eur J CUn Microbiol Infect Dis 1994 13 559-564. 

Lepidi H, Durack DT, Raoult D. Diagnostic methods Current best practices and guidelines for histologic evaluation in infective endocarditis. Infect Dis Clin North Am. 2002 16 339-361. 

Lilly conducted Phase I and Phase II clinical studies on daptomycin in the 1980s and early 1990s for skin and soft tissue infections, bacteraemia and endocarditis.9 In a Phase I safety study to evaluate increasing the dose to 4 mg/kg every 12 hours to treat endocarditis, two of five volunteers exhibited symptoms of muscle toxicity, including elevated creatine phosphokinase (CPK). After observing muscle toxicity with this dosing regimen, Lilly discontinued clinical development of daptomycin in 1991. 

Peacock MG, Philip RN, Williams JC, et al. Serological evaluation of Q fever in humans Enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis. Infect Immun. 1983 41 1089-1098. 

Infections of AVF are less frequent than CLABSI, and usually occur at the cannulation site. Vascular surgeons should evaluate the AVF to determine the need for surgical resection. Regardless, these infections should be treated for 6 weeks, in analogy to subacute bacterial endocarditis. Antibiotic therapy should be guided by culture results and resistance profiles. AVG infections usually require surgical revision with either partial, subtotal or total excision of the graft. 

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