Industrial systems biology

Fig. 1 The integration of systems biology tools with metabolic engineering for advancing industrial biotechnology is herein referred to as industrial systems biology. Industrial systems biology offers the opportunity to introduce new concepts in metabolic engineering and advances the development of cell factories through traditional fermentation for production of natural products and, after the advent of recombinant DNA technology, for the production of recombinant metabolites [1]...

Otero JM, Nielsen J (2009) Industrial Systems Biology. Biotechnol Bioeng 105(3) 439 -60... 

A number of examples of biosystems engineering applied to industrial biotechnology (or industrial systems biology ) have been summarized by Papini et al. [105] and Wittmann [106], including examples for commercially highly important products such as ethanol, butanol, polyhydroxyalkanoates, amino acids, polyke-tides, and antibodies. 

Otero JM, Cimini D, Patil KR, Poulsen SG, Olsson L, Nielsen J. Industrial systems biology of Saccha-romyces cerevisiae enables novel succinic acid cell factory. PLoS One 2013 8 e54144. 

Orenzen PC, Schlimme E (1998) Properties and potential fields of application of transglutaminase preparations in dairying. Bull Int Dairy Fed 332 347 Otero JM, Nielsen J (2010) Industrial systems biology. Biotechnol Bioeng... 

Orjuela A, Yanez AJ, Peereboom L, Lira CT, Miller DJ (2011) A novel process for recovery of fermentation-derived succinic acid. Sep Purif Technol 83 31-37 Otero JM, Cimini D, Patil KR, Poulsen SG, Olsson L, Nielsen J (2013) Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory. PLoS One 8 1-10 Ponnampalam E (1999) Purification of organic acids using anion exchange chromatography. Patent WO9944707... 

Wastewater equalization is necessary to reduce biological system upsets from large variations of influent compositions or other physical parameters such as temperature. Equalization is accomplished by providing sufficient residence time and often mixing energy. Neutralization is often necessary to protect both the treatment system biological activity as well as the materials of construction. Accidental spills of significant impact upon wastewater pH occur relatively frequently in the hydrocarbon industry. 

Banes, E. D. In Calcium Phosphates in Biological and Industrial Systems, Amjad, Z., Ed. 1998, Kluwer Academic Publ., Boston, 21. 

Polymers play a important role in both biological and industrial systems. Recently, there has been much interest in developing methods to apply polymer colloidals. The principle is to employ polymer colloidal beads instead of using large solid particles. 

J. P. Yesinowski, Nuclear magnetic resonance spectroscopy of calcium phosphates, in Z. Amjad (Ed.), Calcium Phosphates in Biological and Industrial Systems, Kluwer Academic Publishers, Norwell, MA, 1998, pp. 103-143. 

The concept of limitation is very attractive both for theorists and experimentalists. It is very useful to find conditions when a selected reaction step becomes the limiting step. We can change conditions and study the network experimentally, step-by-step. It is very convenient to model a system with limiting steps the model is extremely simple and can serve as a very elementary building block for further study of more complex systems, a typical situation both in industry and in systems biology. 

Adsorption is an important unit process in chemical processing, air pollution control, and water and wastewater treatment. In several applications, the adsorbate is a mixture of a number of compounds. Industrial and domestic wastewaters typically contain a wide spectrum of compounds in differing concentrations. Even in single solute systems, biological decay may result in end products that compete with the solute for the available sites on the surface of the adsorbent. It is, therefore, desirable to develop a model to describe the kinetics of multicomponent adsorption. 

Copolymers have been studied extensively for several decades, partly because of their industrial and biological importance, and partly because of their interesting and sometimes perplexing properties. Many physical and mechanical properties of copolymers, which comprise two or more covalently bonded sequences of chemically distinct monomer species, depend on both the comonomer composition and the arrangement of these comonomers in the polymer chain. There may be significant differences, for example, between two polymer systems with the same chemical composition, but one of which has the comonomers randomly distributed in the chain while the other has long blocks of each monomer type. 

Takors R, Bathe B, Rieping M et al (2007) Systems biology for industrial strains and fermentation processes-example amino acids. J Biotechnol 129 181-190... 

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