Industrial biotechnology systems biology

Keywords Metabolic engineering, Systems biology, Industrial biotechnology... 

Introduction The Role of Systems Biology in Industrial Biotechnology. 52... 

Fig. 1 The integration of systems biology tools with metabolic engineering for advancing industrial biotechnology is herein referred to as industrial systems biology. Industrial systems biology offers the opportunity to introduce new concepts in metabolic engineering and advances the development of cell factories through traditional fermentation for production of natural products and, after the advent of recombinant DNA technology, for the production of recombinant metabolites [1]...

Here we will review the impacts of systems biology on industrial biotechnology. Even though we may give examples from many different cell factories, our focus will be on yeast and filamentous fungi, widely used cell factories in industrial biotechnology. 

A number of examples of biosystems engineering applied to industrial biotechnology (or industrial systems biology ) have been summarized by Papini et al. [105] and Wittmann [106], including examples for commercially highly important products such as ethanol, butanol, polyhydroxyalkanoates, amino acids, polyke-tides, and antibodies. 

The amino acid production industry will remain as a fast growing business enterprise until a cheaper and energy efficient process is commercialized. Microbial amino acid production will be exploited to the most possible extend of maximal production capacity and process economics by new innovations in strain improvement, metabolic engineering, and systems biology. Microbial amino acid production holds a promising position in the future of white biotechnology and studies on utilization of feedstock for... 

For Ca /zero order with respect to A. For Ca< /order reaction with respect to the substrate A. Industrial biotechnological processes are run in or near the zero-order regime to maximize the rate. For biosensors, where the signal should be sensitive to the concentration, the first-order regime is desired. Biological processes in living systems (e.g., our body) also run in the first-order regime, as the control of a reaction is more important than the rate. 

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