INDEX activation parameters

I7(x-Methyl-17 -hydroxy-estra-4,9,l l-trien-3-one (Methyltrienolone, N-99). In the course of a steroid total synthesis [293] this compound (Methyltrienolone, N-99) was prepared it was reported [55] to possess 6000% of the androgenic (ventral prostate index), 7500% of the androgenic (seminal vesicles index), and 12,000% of the anabolic (levator ani index) activity of methyltestosterone. Later the anabolic activity was reported [74] to be 30,000% of that of methyltestosterone. As measured by multiple parameters methyltrienolone turned out to be the most hepatotoxic steroid, causing biochemical symptoms of intrahepatic cholestasis [75]. It was also reported [74] to reduce the excretion of 17-ketosteroids and 17-hydroxycorticosteroids and to cause enhancement of the blood coagulation factors V, VII, and X. It also increases the prothrombin content of the plasma [74]. 

Relative Melt Index Potential. Melt indices were obtained from polymer samples by the standard test (ASTM D 1238-73) at 190 C using a weight of 2160 grams. However, melt index values are not just affected by activation parameters, but also by reactor conditions, such as the temperature, monomer concentration, and residence time. Therefore for clarity in this report we have normalized melt index values against those of a reference catalyst run under the same reactor conditions. We call the normalized value the relative melt index potential (RMIP) because it is... 

Temperature dependence of the fluorescence quantum yields and fluorescence lifetimes of frans-4,4 -di-fert-butylstilbene in n-hexane and n-tetradecane allowed to define the index of refraction dependence of the radiative rate constants, kf= (3.9 — 1.8) X 10 s, and fluorescence lifetime [78]. This relationship was used to calculate torsional relaxation rate constants ktp> for traws-4,4 -dimethyl- and frans-4,4 -di-ferf-butylstilbene in the n-alkane solvent series. It was found that activation parameters for ktp, based on Eyring s transition state theory, adhered to the medium-enhanced thermodynamic barrier model relationship, AHtp = AHt + aEr, and to the isokinetic relationship. The isokinetic relationship between the activation parameters for the parent frans-stilbene led to an isokinetic temperature of P = 600K and brings it into agreement with the isokinetic temperature for activation parameters based on estimated microviscosities, qp, experienced by stilbene in its torsional motion. The authors concluded that only microviscosities raflier than shear viscosities, q, can be employed in the expression ktp = ktSq — b, when a = b. These data clearly indicated the important role of the media dynamics in the stilbene cis-trans photoisomerization. 

AHpr, Spr, AFpr - thermodynamic parameters of products AH, AS i AF -activation parameters of reactions. Indexes p and e by kinetic and thermodynamic characteristics mean calculated and experimental values. 

The guarded hot-plate method can be modified to perform dry and wet heat transfer testing (sweating skin model). Some plates contain simulated sweat glands and use a pumping mechanism to deUver water to the plate surface. Thermal comfort properties that can be deterrnined from this test are do, permeabihty index (/ ), and comfort limits. PermeabiUty index indicates moisture—heat permeabiUty through the fabric on a scale of 0 (completely impermeable) to 1 (completely permeable). This parameter indicates the effect of skin moisture on heat loss. Comfort limits are the predicted metaboHc activity levels that may be sustained while maintaining body thermal comfort in the test environment. 

The PMV index can be determined when the activity (metabolic rate) and the clothing (thermal resistance) are estimated and the following environmental parameters are measured air temperature, mean radiant temperature, relative air velocity, and partial water vapor pressure (see ISO EN 7726). 

The PMV index can be used to check whether a given thermal environment complies with specified comfort criteria and to establish requirements for different levels of acceptability. By setting PMV = 0, an equation is established that predicts combinations of activity, clothing, and environmental parameters that will provide a thermally neutral sensation. Figure 6.1 shows the optimal operative temperature as a function of activity and clothing for different levels of acceptability. 

The CHI index is reportedly a relevant parameter in quantitative structure-activity relationship (QSAR) studies [41]. With this approach, log P could be determined in the range -0.45more than 25000 compounds with excellent reproducibility (within 2 index units) and reported in a GlaxoSmithKline database [11]. Two main drawbacks were identified using this approach (i) the assumptions used in Ref [7], i.e. that S is constant for all compounds and that the system dwell volume is excluded in calculations, yield some discrepancies in the resulting log P, and (ii) the set of gradient calibration... 

E I is a kinetic chimera Kj and kt are the constants characterizing the inactivation process kt is the first-order rate constant for inactivation at infinite inhibitor concentration and K, is the counterpart of the Michaelis constant. The k,/K, ratio is an index of the inhibitory potency. The parameters K, and k, are determined by analyzing the data obtained by using the incubation method or the progress curve method. In the incubation method, the pseudo-first-order constants /cobs are determined from the slopes of the semilogarithmic plots of remaining enzyme activity... 

Doelman P, Jansen E, Michels M, Van-Til M (1994) Effects of heavy metals in soil on microbial diversity and activity as shown by the sensitivity-resistance index, an ecological relevant parameter. Biol Fertil Soils 17 177-184... 

The second structural property described by the 4ypc index is the substitution pattern on the benzene ring. The value of the 4ypc index increases sharply with the degree of substitution, while in the isomeric classes of substituted benzenes it increases with the proximity of substituents. Thus, this structural parameter has also been found to be very useful in describing activities and properties of polysubstituted benzenes [103], chlorinated benzenes [279], and polychlorinated biphenyls [286]. 

The frequency of a single-mode laser inside the spectral gain profile of its active medium is mainly determined by the eigenfrequency of the active laser cavity mode. Therefore any instability of resonator parameters, such as variation of cavity length, mirror vibrations or thermal drifts of the refractive index will show up as frequency fluctuations and drifts of the laser line. 

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