Inden indole

Benzo[6]thiophene forms continuous solid solutions with molecules of similar molecular geometry (e.g., indene, indole, or isoquinoline), but eutectics with molecules of significantly different geometry (e.g., 3-methylisoquinoline, 2-methyl- and 2,6-dimethylnaphthalene, or dibenzothiophene).197,198 Naphthalene and benzo[6]thiophene form a system of limited solid solutions,54,199 which accounts for the difficulties encountered in their separation (see Section II, B). 

These compounds are also derivatives of acetic acid, but in this case the substituent at the 2-position is aheterocycle or related carbon cycle (Figure 13.6). This does not significantly affect the acidic properties of these compounds. The heteroarylacetic acid NSAIDs marketed can be further subclassified into indene/indoles, the pyrroles, and the oxazoles, as shown in Figures 13.7 through 13.9, respectively. 

This general method has been used by Parham and coworkers4 to transform indenes into /3-halonaphthalenes. Other references in the literature indicate that tins method is also useful for the conversion of pyrroles to -substituted pyridines and of indoles to j8-lialoquinolines.3... 

Indenes, 34 Indole [ 1H Indole], 10 INDOLE, 3-BENZOYL- [METI1ANONE, 1//-INDOL-3-YLPHENYL-], 8 INDOLE, 3-BENZYL- [lff-INDOLE, 3-(PHENYLMETHYL)-], 8 INDOLE, 5-CARBOETHOXY-2-METHYL-] 17/-1NDOLE-5-C ARBOXYLIC ACID, 2-METHYL, ETHYL ESTER], 72 Indole, S-carlioethoxy-2-methyI-3-niethyl-thio-11H Indole-5-carboxyhc acid, 2-methyl-3-(methylthio)-, ethyl ester, 73... 

Imidazoles 775 /J-Iminosulphones 640 /J-Iminosulphoxides, synthesis of 69 Inclusion compounds 59, 287 Indanols 256 Indanones 338 Indenes 267 Indoles 323... 

Indene, 6, 7-dimethox y-3-meti iy l-2 -CARBETHOXY-, 40, 43 Indene, hydroxylation of, 41, 53 Indole, methylation to 1-methylindole, 40,68... 

C jH2,NOSi) see Indanorex (lS-cii)-2,3-dihydro-l//-indene-l,2-diol (G7H10O2 6752S-22-7) see Indinavir sulfate (laS)-la,6a-dihydro-6//-indenori,2-6]oxirene (CgHjO 67528-26-1) see Indinavir sulfate (2,3-dihydro-l//-inden-4-yl)carbamimidothioic acid methyl ester monohydriodide (C, H 1N2S 40507-77-5) see Indanazoline 23-dibydro-l//-indole-2-carboxylic acid ethyl ester (C iH, N02 50501-07-0) see Perindopril... 

Allen CC, DR Boyd, Ml Larkin, KA Reid, ND Sharma, K Wilson (1997) Metabolism of naphthalene, 1-naphthol, indene, and indole by Rhodococcus sp. strain NCIMB 12038. Appl Environ Microbiol 63 151-155. 

Replacement of one or more of the C or N atoms of the indole nucleus by atoms of N, C, O or S will result in dialkyltryptamine analogs some of which are very likely to be psychedelic. Among the indole analogs are isoindole, indene, indazole, diazindoles, benzo-furan, benzothiophene and benzimidazole. The syntheses of several such compounds follows. 

C) with an indole-like odor. It is prepared by a Prins reaction from indene and formaldehyde in the presence of dilute sulfuric acid [194]. It is used in perfumes for soap and detergents. 

In a somewhat different approach, Asahi Glass KK have claimed [132] that the addition of a transition metal salt (e. g., cobalt-, copper-, lead-, cerium-, bismuth-, manganese-, chromium-, iron- chloride, or cobalt fluoride, etc.) greatly improves the ECF production of perfluorobicyclic compounds, derived from naphthalene, indene, benzofuran, phthalimide, indole, quinolizine, benzotriazole, and quinoline. 

Just as there is a family of heterocycles isoelectronic with the indene monoanion (13)27 (indole, isoindole, indolizine, pseudoazulenes, etc.), there are several hundred possible systems derived from the pentalene dianion (14).2 Scheme 3 shows some examples (15-20) derived (formally) from each canonical form of 14. 

Our aromaticity-determining reactions for the three heterocycles are endothermic by 70, 40, and 48 kJ mol-1, to be compared with the exothermicity for the corresponding carbocycle, indene, of nearly 9 kJ mol-1. Indole, benzofuran, and benzothiophene are truly aromatic species in terms of thermochemical stabilization. 

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