ARBOXYLIC ACIDS

D-0i-t-Butoxycarbonylamino-0i-(p-hydroxyphenyl)acetamidol -3-(1,2,3-triazol-5-ylthiomethyl)-3[Pg.263]

Chemical Name 7-[D-(-)-0 -(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl )acetamidol -3-[(1-methyl-1 H-tetrazol-5-yl)thiomethyl] -3[Pg.266]

D-(-)-a-Amino-p-hydroxyphenylacetamido] -3-[5-(1 -methyl-1,2,3,4-tetrazolyl)-thiomethyl]-A3[Pg.266]

To a suspension of 3.0 g of 7-[D-(-)-a-amino-p-hydroxyphenylacetamido] -3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl] -A3anhydrous potassium carbonate. After the solution was formed, 15 ml of ethyl acetate was added to the solution, and 1.35 g of 4-ethyl-2,3-dioxo-1 -piperazinocarbonyl chloride was added to the resulting solution at 0°C to 5°C over a period of 15 minutes, and then the mixture was reacted at 0°C to 5°C for 30 minutes. After the reaction, an aqueous layer was separated off, 40 ml of ethyl acetate and 10 ml of acetone were added to the aqueous layer, and then the resulting solution was adjusted to a pH of 2.0 by addition of dilute hydrochloric acid. Thereafter, an organic layer was separated off, the organic layer was washed two times with 10 ml of water, dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The residue was dissolved in 10 mi of acetone, and 60 ml of 2-propanol was added to the solution to deposit crystals. The deposited crystals were collected by filtration, washed with 2-propanol, and then dried to obtain 3.27 g of 7-[D-(-)-a-(4-ethyl-2,3-dioxo)-1 -piperazinocarbonylamino)-p-hydroxyphenylacetamido] -3-[5-(1 -methyl-1,2,3,4-tetrazolyl)thiomethyl]-A product forms crystals, MP 1BB°C to 190°C (with decomposition). 

A solution of B g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)distilled water and another BO ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under... 

Chemical Name (6R,7R)-1-l(Z)-2-(2-Aminothiazol-4-yl)-2-(2[Pg.272]

Chemical Name 1-Ethyl-6,7-methylenedioxy-4(1 H)-oxocinnoline-3[Pg.345]

About 23 g (0.095 mol) of 1-ethyl-6,7 methylenedioxy-4(1H)-oxocinnoline-3concentrated hydrochloric acid and 200 ml of acetic acid. The resultant reaction mixture was heated under reflux for IB hours. The excess acids were removed under vacuum, and the residue was taken up in 150 ml of a 5% sodium bicarbonate solution. The resultant solution was treated with 5 g of charcoal and filtered. The filtrate was made acidic by the addition of hydrochloric acid and the resulting precipitate was removed by filtration. 23 g, representing a yield of 91.6% of 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3[Pg.346]

Chemical Name 5,5 -[ (2-Hydroxy-1,3-propanediyl)bis-(oxy)l bis[4-oxo4H-1-benzopyran-2[Pg.393]

The mixture was refluxed for 45 minutes, cooled under nitrogen, and 19.8 g (0.10 mol) of 1-amino-1-cyclohexanereaction mixture was poured into 200 ml of cold water with stirring and the two-phase mixture clarified by filtration. Dilute sodium hydroxide solution was added to the filtrate at 5° to 10°C to pH 5.4. 

Chemical Name 2, 4 -Difluoro4-hydroxy-[ 1,1 -biphenyl] -3Common Name Difluorophenyl salicylic acid Structural Formula cooh... 

Chemical Name 3,3-Dlmethyl-7-oxo-6- [ [ (2-propenylthio)acetyll amino] -4-thia-1 -azabi-cycio[3.2.0] -heptane-2[Pg.1178]

Parts of pyrazine-2,3-dicarboxamide (1 mol) is slurried in 1,000 parts of 1 N aqueous sodium hydroxide. The reaction mixture is heated at 95°C to 98°C until a clear solution results. Thereupon the mixture is cooled with ice to about 5°C and acidified to approximately a pH of 1. The cold reaction mixture is allowed to stand until precipitation of the pyrazlne-2[Pg.1330]

Parts of pyrazine-2reaction vessel provided with an intake for Inert gas. The reaction mixture is heated in a bath held at 220°C and nitrogen is introduced. The solid material melts and effervesces and sublimed pyrazinamide vapors are carried out of the reaction vessel in the nitrogen stream. They are introduced into a suitably cooled condenser, condensing in the form of a white sublimate. After the reaction is proceeding vigorously the bath temperature is raised to 255 C and then gradually and slowly allowed to drop to 190°C over a period of time sufficient to permit the reaction to go substantially to completion. The sublimed pyrazinamide, if desired, is further purified by recrystallization from water or alcohol. 

Chloro-1 -ethyl-6-fluoro-4-0x0-1,4-di-hydroquinoline-3[Pg.1622]

Indenes, 34 Indole [ 1H Indole], 10 INDOLE, 3-BENZOYL- [METI1ANONE, 1//-INDOL-3-YLPHENYL-], 8 INDOLE, 3-BENZYL- [lff-INDOLE, 3-(PHENYLMETHYL)-], 8 INDOLE, 5-CARBOETHOXY-2-METHYL-] 17/-1NDOLE-5-C ARBOXYLIC ACID, 2-METHYL, ETHYL ESTER], 72 Indole, S-carlioethoxy-2-methyI-3-niethyl-thio-11H Indole-5-carboxyhc acid, 2-methyl-3-(methylthio)-, ethyl ester, 73... 

Many c arboxylic acids lose carbon dioxide on either direct or sensitized irradiation, and in some cases (4.10) the evidence points to the operation of an initial electron-transfer mechanism rather than primary a-cleavage. Cleavage occurs readily with acyl halides, and this can lead to overall decarbonylation (4.11). Aldehydes also cleave readily, since the (0=)C—H bond is more prone to homolysis than the (0=)C—C bond. This offers a convenient method for replacing the aldehydic hydrogen by deuterium in aromatic aldehydes (4.12), and a similar initial reaction step accounts for the production of chain-lengthened amides when tormamide is irradiated in the presence of a terminal alkene (4.13). 

Figure 9.50 Correlation between Hie percentage dose absorbed after nasal administration and molecular weight 4oxo-4H-l-benzopyran-2 arboxylic acid (chromocarb) ( ) paminohippuric acid (A) sodium cromoglicate (O) inulin ( ) dextran ( ) r = -0.996.

Alcohols p-Bromophenacyl bromide. 2,4-Dinitrobenzenesulfenyl chloride. 3,5-Dinitro-benzoyl chloride. o-Naphthylisocyanate. 4 -Nitroazobenzene.4Phenylazobenzoyl chloride. p-Phenylsulfonylbenzoyl chloride. p-Propionylisocyanate. 

Cyclization combined with chlorination of the newly formed ring occurs when an iminoH arboxylic acid is heated with phosphorus oxychloride the yield is low when R = Me. 

Coumalic acid Cumalic acid EINECS 207-899-0 NSC 22978 2-Oxopyran-5-carboxylic acid 2-Pentenedioic acid, 4-(hydroxymethylene)-, delta-lactone a-Pyrone-5-carboxylic acid 2H-Pyran- arboxylic acid, 2-oxo-. Used in chemical synthesis. Crystals mp= 203-205 (dec) bpi20 = 218 Xm = 240, 290 nm (s =... 

Deprotonation. The presence of a chelator unit in the molecule facilitates and Jirects the deprotonation. For example. The H-6 of 2-/-butyl-l-methoxymethyl-3- iethyl-l,2,3,4-tetrahydropyrimidin-4-one, H-2 of A-methylindole and indole-l-.arboxylic acid, H-4 of l-triisopropylsilylgramine" are selectively removed. 

Condensation of naphthalene-l,4,S-trx arboxylic acid with 4,4 -diacetoxydiphenyl 79.7 121... 

Amino-3-methoxy-3-oephem-4[Pg.270]

To a solution of 7 3-(a-p-hydroxyphenyl-a-carboxyacetamido-7a-methoxy-3-(1-methyl-tstrazol-5-yl)thiomethyl-1-oxadethia-3-cephem-4-carboxylicacid (359 mg) in methanol (7 ml) Is added a solution of sodium 2-ethylhexanoate in methanol (2 mols/liter 1.73 ml) at room temperature. After stirring for 10 minutes, the reaction mixture is diluted with ethyl acetate, stirred for 5 minutes, and filtered to collect separated solid, which is washed with ethyl acetate, and dried to give disodium salt of 7 3-(a-p-hydroxyphenyl-amethyl-tetrazol-5-vl)thiomethyl-1-oxadethia-3-cephem-4[Pg.1040]

Chemical Name 3,3-DimethyI-7-oxo-6-ni-oxo-2-phenoxypropyl)amino] -4-thia-l-azabicy-cyclo[3.2.0] heptane-2[Pg.1201]

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