In tnfluoroacetic acid

Protect glycine as its Boc derivative and anchor this to the solid support Remove the pro tecting group and treat with Boc protected phenylalanine and DCCI Remove the Boc group with HCl then treat with HBr in tnfluoroacetic acid to cleave Phe Gly from the solid support... 

The products formed by oxidative deavage of an alkene depend on the alkene structure and the agent used Acid fluorides are formed by ozonization of per-fluoroalkenes in tnfluoroacetic acid [3t5] (equation 28)... 

Tnfluoroacetic acid is a useful medium for a number of oxidation reactions It is highly resistant to strong oxidants, even to permanganates and chromates For instance, various alkanes, cycloalkanes, and arenes can be oxidized degradatively by potassium permanganate in tnfluoroacetic acid under mild conditions [28]... 

Clear polymer, mol wt 22,000-45,000, mp 283-319. d 1,20 (solution-cast film). Insol in most solvents. Sol in formic acid. Slightly sol in tnfluoroacetic acid. use Industrial fiber fiber-reinforced rubber products. 

Catalytic hydrogenation of tnfluoroacetic acid gives tnfluoroethanol in high yield [73], but higherperfluorocarboxybc acids and their anhydndes are reduced much more slowly over rhodium, iridium, platinum, or ruthenium catalysts [7J 74] (equation 61) Homogeneous catalysis efficiently produces tnfluoroethanol from tnfluoroacetate esters [75] (equation 61)... 

Sodium nitrite in dimethylformamide acts as a nucleophile and reacts with perfluoropropene to generate a perfluoroalkyl nitrite anion The intermediate carbanion undergoes intramolecular nitrosation with loss of carbonyl difluoride to give tnfluoroacetic acid upon hydrolysis [5] (equation 6)... 

The discussion of acylation reactions in this chapter is focused on fluonnated carboxylic acid derivatives and their use to build up new fluorine-containing molecules of a general preparative interest Fifteen years ago, fluonnated carboxylic acids and their derivatives were used mainly for technical applications [/] Since then, an ever growing interest for selectively fluonnated molecules for biological applications [2, 3, 4, 5] has challenged many chemists to use bulk chemicals such as tnfluoroacetic acid and chlorodifluoroacetic acid as starting materials for the solution of the inherent synthetic problems [d, 7,, 9]... 

A variety ot media have been used for the Wallach fluormation reaction anhydrous hydrogen fluoride alone or with cosolvents such as methylene chloride, benzene, or tetrahydrofuran and hydrogen fluoride-pyridine alone or with co solvents such as benzene, glyme, or acetic acid [42,43,46 50] Solutions of cesium fluoride, tetraethylammomuin fluoride, or tetrabutylammomum fluoride in strong acids such as methanesulfonic acid or tnfluoroacetic acid with numerous cosolvents have also been studied [48, 49]... 

Compared with reactions in other strong acids used in hydrogenations, such as hydrochloric, sulfuric, and tnfluoroacetic acid, reactions in hydrofluoric acid are faster and proceed more selectively under milder conditions [2]... 

A very common oxidizing reagent is peroxytrifluoroacetic acid, which is usually generated in situ from tnfluoroacetic acid [29, 30, 31] or tnfluoroacetic anhydride [32, 33, 34] and hydrogen peroxide Peroxytrifluoroacetic acid is one of the most efficient epoxidizing reagents [35] It can be used to prepare epoxides... 

Halothane remains the leading anesthetic m many parts of the world However, it is believed to cause a fulminant hepatitis in rate, susceptible individuals, especially after repeated use within short intervals It was believed, but now disputed, that this hepatitis resulted from toxic metabolites [2] (Actually, the major metabolite is tnfluoroacetic acid, which as a salt in body fluids, is benign) As rare as the hepatitis cases were (1 m 20 000), they frequently resulted m malpractice suits, especially m the United States This problem led to a search for more ideal nonflammable anesthetics that are also metabolized to a lesser extent [2]... 

Desflurane can be made by fluonnation of isoflurane with potassium fluonde [/J] or with bromine tnfluonde [14] (equation 2) Although approximately six times more desflurane than isoflurane is required for anesthesia, it achieves the anesthetic state and the patient recovers from this state more rapidly This feature seems to be of interest to some anesthesiologists One negative property is that it irritates the breathmg passageway, especially in children Desflurane is flammable at higher levels of anesthetic use It is the least metabolized of all the commercial anesthetics, producing tnfluoroacetic acid and fluonde ion [75]... 

Although fluonnation of peroxoanions [oxygenated material is the preparation offluoroxy compounds The simplest, trifluoromethyl hypofluorite, can be prepared almost quantitatively by the action of fluorine on carbonyl fluoride (fluorophosgene) in the presence of various catalysts [ 5, 84] Addition of fluorine to tnfluoroacetic acid or its sodium salt [56] gives rise to F3CF(OF)2 Long-chain fluoroxy compounds can also... 

Tnfluoromethyl-l-phenylethyl tosylate has been used to differentiate as shown in Table 1, the solvolytic power of three fluorinated solvents and to compare these with formic and acetic acids The three fluorinated solvents are tnfluoroacetic acid, tnfluoroethanol, and 1,1,1,3,3,3-hexafluoroisopropyl alcohol [5 ]... 

Tnfluoroacetic anhydnde in a mixture with sulfuric acid is an efficient reagent for the sulfonylation of aromatic compounds [44] The reaction of benzene with this system in nitromethane at room temperature gives diphenyl sulfone in 61% yield Alkyl and alkoxy benzenes under similar conditions form the corresponding diaryl sulfones in almost quantitative yield, whereas yields of sulfones from deactivated arenes such as chlorobenzene are substantially lower [44] The same reagent (tnfluoroacetic anhydride-sulfunc acid) reacts with adamantane and its derivatives with formation of isomeric adamantanols, adamantanones, and cyclic sultones [45]... 

Tnfluoroacetic anhydride is an efficient dehydrating reagent [46, 47] In the presence of pyndine, it smoothly dehydrates amides and aldoximes to the correspond ing nitriles [46] and adducts of CH-acids and 1,2,3-indantnone [47] (equation 20)... 

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