Tnfluoroacetic anhydnde

Tnalkylindoles undergoFnedel-Crafts reactions at position 6, however, in tnfluoroacetic anhydride the a-methyl group of 1,2,3-trimethylindole is acylated through an intermediate enamine [41, 42] (equation 27) Similarly, tnfluoroacetic anhydnde acylates the double bond of the a-methylene compound shown [42] (equation 28)... 

From semiamidals, the correspondmg tnfluoromethyl substituted N-acyl mines [25, 28], 1,3-diambutadienes [27], N-sulfonyl mines [5, 29], N sulfinyl mines [30], and N-phosphoryl mines [31] can be obtamed in high yields on reaction with powerful dehydratmg realms like POC -pyndine or tnfluoroacetic anhydnde-pyndme [2, 5]... 

Tnfluoroacetic anhydnde in a mixture with sulfuric acid is an efficient reagent for the sulfonylation of aromatic compounds [44] The reaction of benzene with this system in nitromethane at room temperature gives diphenyl sulfone in 61% yield Alkyl and alkoxy benzenes under similar conditions form the corresponding diaryl sulfones in almost quantitative yield, whereas yields of sulfones from deactivated arenes such as chlorobenzene are substantially lower [44] The same reagent (tnfluoroacetic anhydride-sulfunc acid) reacts with adamantane and its derivatives with formation of isomeric adamantanols, adamantanones, and cyclic sultones [45]... 

Fluoroalkyl iodides are oxidized at the lodme atom by trifluoroperoxyacetic aeld [779, 720] or by a mixture of tnfluoroacetic anhydnde and hydrogen peroxide [77iodo]alkanes are formed in almost quantitative yields [776, 117 119]... 

Catalytic hydrogenation of tnfluoroacetic acid gives tnfluoroethanol in high yield [73], but higherperfluorocarboxybc acids and their anhydndes are reduced much more slowly over rhodium, iridium, platinum, or ruthenium catalysts [7J 74] (equation 61) Homogeneous catalysis efficiently produces tnfluoroethanol from tnfluoroacetate esters [75] (equation 61)... 

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