Tnfluoroacetic anhydride

Tnalkylindoles undergoFnedel-Crafts reactions at position 6, however, in tnfluoroacetic anhydride the a-methyl group of 1,2,3-trimethylindole is acylated through an intermediate enamine [41, 42] (equation 27) Similarly, tnfluoroacetic anhydnde acylates the double bond of the a-methylene compound shown [42] (equation 28)... 

Azupyrene, a nonbenzenoid 4tu tt-eleetron system, undergoes electrophilic substitution in tnfluoroacetic anhydride suggesting aromatic character, which is corroborated by spectral evidence [43] (equation 29)... 

Tnfluoroacetic anhydnde in a mixture with sulfuric acid is an efficient reagent for the sulfonylation of aromatic compounds [44] The reaction of benzene with this system in nitromethane at room temperature gives diphenyl sulfone in 61% yield Alkyl and alkoxy benzenes under similar conditions form the corresponding diaryl sulfones in almost quantitative yield, whereas yields of sulfones from deactivated arenes such as chlorobenzene are substantially lower [44] The same reagent (tnfluoroacetic anhydride-sulfunc acid) reacts with adamantane and its derivatives with formation of isomeric adamantanols, adamantanones, and cyclic sultones [45]... 

Tnfluoroacetic anhydride is an efficient dehydrating reagent [46, 47] In the presence of pyndine, it smoothly dehydrates amides and aldoximes to the correspond ing nitriles [46] and adducts of CH-acids and 1,2,3-indantnone [47] (equation 20)... 

Tnfluoroacetic anhydride is a good reagent for various cychzations In the presence of a catalytic amount of phosphonc acid, it is used for the macrocyclization of oi-(2-thienyl)alkanoic acids [48] (equation 21)... 

A useful oxidizing reagent is silver(III) tristrifluoroacetate which can be generated from silver peroxide (AgO) and a tnfluoroacetic acid-tnfluoroacetic anhydride mixture [5f] This reagent readily oxidizes alicyclic and bicyclic hydro... 

Tnfluoroacetic anhydride Acetic acid, trifluoro-, anhydride ... 

Fluoroalkyl iodides are oxidized at the iodine atom by trifluoroperoxyacetic add [779, 720] or by a mixture of tnfluoroacetic anhydride and hydrogen peroxide [77iodo]alkanes are formed in almost quantitative yields [116, 117 119]... 

A very common oxidizing reagent is peroxytrifluoroacetic acid, which is usually generated in situ from tnfluoroacetic acid [29, 30, 31] or tnfluoroacetic anhydride [32, 33, 34] and hydrogen peroxide Peroxytrifluoroacetic acid is one of the most efficient epoxidizing reagents [35] It can be used to prepare epoxides... 

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