In rabbit model

Caspofungin Strong response in rabbit model Susceptible in vitro Resistant in vitro Susceptible in vitro Susceptible in vitro... 

Historically, the roots of modem drng discovery can be traced back to German scientist Panl Ehrlich (1854-1915), who, early in the twentieth century synthesized and tested a library of few hundred compounds in rabbit models. As a result, the first effective treatment against syphilis, Salvarsan, was discovered in 1910 [10]. With a nnmber of chemical companies following Ehrlich s... 

Louie A, Kaw P, Banegee P, Liu W, Qien G, dUler MH. Impact of order of initiation of flu-cona le and amphotericin B in sequential cr combination ther y on killing of Candida albicans in vitro and in rabbit model of endocarditis and pyelonephritis. Antimicrc Agents ChemoOier (2001) 45,485-10. 

Libera RD, Melo GB, et al. Assessment the use of ciyopieserved freeze dried amniotic membrane (AM) for reconstruction of ocular surface in rabbit model. Arq Bras Oftalmol 2008 71(5) 669-73. 

Cave G, Harvey M, Prince G, Lahner D, Desmet J. Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. Anaesthesia 2010 65 792-8. 

These hydrogels remained transparent and stable for the entire study period of 9 months. The viscoelastic properties of these hydrogels were found to be very close to that of the natural vitreous. Pritchard et al. have evaluated a 5 wt% uncross-linked PEG sol in phosphate buffer as a vitreous substitute in rabbit model... 

Ouyang, H. W. Goh, J. C. H. Lee, E. H. Viability of allogeneic bone marrow stromal cells following local delivery into patella tendon in rabbit model. Cell Transplant. 2004,13, 649-657. 

Bone defects surgically produced in sheep and rabbit models, have been treated with freeze dried methylpyrrohdinone chitosan [334-336]. hi view of improving bone tissue reconstitution with chitosan associated with calcium phosphate. Microscopic and histological analyses showed the presence of an osteogenic reaction moving from the rim of the surgical lesion toward the center. In control lesions, dense fibrous tissue, without the characteristic histoarchitecture of bone was observed. 

Ajmal, N. et al. The effectiveness of sodium 2-mercaptoethane sulfonate (Mesna) in reducing capsular formation around implants in a rabbit model. Blast. Reconstr. Surg., 112, 1455, 2003. 

Fishman, P. G., Peyman, G. A., and Lesar, T. (1986). Intra-vitreal liposome-encapsulated gentamicin in a rabbit model,... 

A rabbit model of 2, 3 -dideoxycytidine neurotoxicity. Lab Invest 66(l) 63-74 Apostolski S, McAlarney T et al (1993) The gpl20 glycoprotein of human immunodeficiency virus type 1 binds to sensory ganghon neurons. Ann Neurol 34(6) 855-863 Araujo AP, Nascimento OJ et al (2000) Distal sensory polyneuropathy in a cohort of HIV-infected children over five years of age. Pediatrics 106(3) E35 Authier FJ, Gheradi RK (2003) Peripheral neuropathies in HIV-infected patients in the era of HAART. Brain Pathol 13(2) 223-228... 

There have been recent studies on the importance of NO in modulating skin blood flow in both normal animals and in inflammatory models. Khan etiU. (1993), using laser-Doppler techniques, showed that the NOS inhibitor L-NAME inhibited rabbit ear blood flow. It was possible to do this chronically for up to 2 weeks using implanted osmotic pumps. Pons et id. (1993) also used laser Doppler to show that the vasodilator eflFect of LPS in rabbit skin, which mimics the efiect of Gram-negative bacteria, was likely to involve both i-NOS and IL-1. We have already discussed the damaging eflPects of neutrophils... 

Kassell (Takahashi et al., 1993) has described the activity of a novel tropolone U88999E in a rabbit model of cerebral vasosjrasm. U88999E inhibits lipid peroxidation and acts as a calcium antagonist. Kassell showed that the compound relaxed preconstricted arterial rings in vitro (potency slightly less than flunarizine or dil-tiazem) and that it reduced vasospasm of basilar arteries after rabbit subarachnoid haemorrhage (Takahashi etal., 1993). 

Albee, W.E., Jacobs, J., Phillips, M., Fisher, L., Panetta, J.A. and Gidda, J.S. (1992). The healing and protective effects of LY213829 in a model of formalin-immune mediated rabbit colitis. Gastroenterology 102, A589. 

In vivo roles of CXCR1 and CXCR2 and their ligands were investigated using rabbits in which the orthologues of IL-8 and its two receptors have been identified. Intravenous injection of a neutralizing anti-IL-8 antibody prevented neutrophil accumulation and activation in a model of reperfusion tissue injury... 

Figure 4. In vivo release experiments for dDAVP (4a) and SRIF (4b) in various cubic phases injected subcutaneously and intramuscularly in a rabbit model. The compositions of the samples are listed in Table n.

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